| Gp96蛋白的免疫学及其临床应用研究进展 |
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| 引用本文： | 陈才伟,贾晓娟,孟颂东,刘文军.Gp96蛋白的免疫学及其临床应用研究进展[J].生物工程学报,2011,27(5):704-711. |
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| 作者姓名： | 陈才伟 贾晓娟 孟颂东 刘文军 |
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| 作者单位： | 中国科学院微生物研究所,中国科学院病原微生物与免疫学重点实验室,北京,100101 |
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| 基金项目： | 国家高技术研究发展计划 (863计划) (No. 2011AA10A215) 资助。 |
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| 摘 要： | 热休克蛋白Gp96属于HSP90家族，是内质网中最丰富的蛋白质之一，在细胞内发挥着分子伴侣的作用。在天然免疫中，Gp96则通过与Toll样受体等相互作用刺激抗原呈递细胞 (如DC等) 产生各种细胞因子激活免疫系统；而在获得性免疫中，Gp96抗原胶通过抗原交叉呈递给MHC-I类分子，诱发机体抗原特异性细胞毒T细胞免疫应答，清除病原物感染和肿瘤；近年来的研究还发现Gp96具有免疫佐剂的功能。以下从Gp96的生物学特性、免疫学机制以及其在抗病原感染和抗肿瘤免疫中的应用等方面做一小结，为设计以Gp96-抗原肽为新一代疫苗的临床研究提供理论基础。
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| 关 键 词： | 热休克蛋白，Gp96，免疫佐剂，抗原交叉呈递 |
| 收稿时间： | 2011/2/25 0:00:00 |
Overview of Gp96 mediated immunity |
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| Caiwei Chen,Xiaojuan Ji,Songdong Meng and Wenjun Liu.Overview of Gp96 mediated immunity[J].Chinese Journal of Biotechnology,2011,27(5):704-711. |
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| Authors: | Caiwei Chen Xiaojuan Ji Songdong Meng and Wenjun Liu |
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| Institution: | CAS Key Laboratory of Pathogenic Microbiology and Immunology, Institute of Microbiology, Chinese Academy of Sciences, Beijing 100101, China;CAS Key Laboratory of Pathogenic Microbiology and Immunology, Institute of Microbiology, Chinese Academy of Sciences, Beijing 100101, China;CAS Key Laboratory of Pathogenic Microbiology and Immunology, Institute of Microbiology, Chinese Academy of Sciences, Beijing 100101, China;CAS Key Laboratory of Pathogenic Microbiology and Immunology, Institute of Microbiology, Chinese Academy of Sciences, Beijing 100101, China |
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| Abstract: | As a member of the HSP90 family, heat shock protein (HSP) Gp96 is one of the most abundant proteins in the endoplasmic reticulum (ER), which displayed important molecular chaperones function in cells. Gp96 can stimulate the production of cytokines by activating the antigen presentation cells (dendritic cell, DC, etc) in innate immunity. It is capable of eliciting an antigen-specific cytotoxic T lymphocyte (CTL) immune response to eliminate pathogens and tumors by facilitating antigen cross-presentation in adaptive immunity. Gp96 is also an ideal adjuvant in many recent researches. Here, we review the progress that addresses the role of biological characteristics, immunogenic mechanism that may be involved in the induction of anti-infection immune response and antitumor immunity, which may guide the new vaccine strategies with the knowledge of Gp96-antigen complexes. |
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| Keywords: | heat shock protein Gp96 adjuvant antigen cross-presentation |
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