| 牛布鲁氏菌病阳性血清国家标准品的研制 |
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| 引用本文： | 李翠,关孚时,戴志红,蒋卉,温芳,陆连寿,王在时.牛布鲁氏菌病阳性血清国家标准品的研制[J].生物工程学报,2011,27(5):812-816. |
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| 作者姓名： | 李翠 关孚时 戴志红 蒋卉 温芳 陆连寿 王在时 |
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| 作者单位： | 军事医学科学院微生物流行病研究所 病原微生物与生物安全国家重点实验室,北京 100071;军事医学科学院微生物流行病研究所 病原微生物与生物安全国家重点实验室,北京 100071;军事医学科学院微生物流行病研究所 病原微生物与生物安全国家重点实验室,北京 100071;军事医学科学院微生物流行病研究所 病原微生物与生物安全国家重点实验室,北京 100071 |
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| 基金项目： | 国家重大科技专项 (Nos. 2009ZX10004-204, 2008ZX10004-015) 资助。 |
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| 摘 要： | 手足口病是由多种肠道病毒感染导致的一种急性儿科传染病。近年来,我国肠道病毒71型 (EV71) 手足口病发病率急剧上升,重症病例时有报道,严重威胁儿童健康。临床上对于重症手足口病的治疗缺乏有效手段,主要以对症治疗和支持疗法为主。静脉注射人免疫球蛋白由健康献血员血浆提取纯化而来,含有包括EV71在内的多种肠道病毒的中和抗体,可作为重症手足口病被动免疫和免疫调节的重要手段,值得关注。
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| 关 键 词： | 肠道病毒71型 手足口病 免疫球蛋白 中和抗体 |
| 收稿时间： | 2011/1/20 0:00:00 |
Preparation and characterization of follwing the national standard anti-Brucella abortus serum, bovine |
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| Cui Li,Fushi Guan,Zhihong Dai,Hui Jiang,Fang Wen,Lianshou Lu and Zaishi Wang.Preparation and characterization of follwing the national standard anti-Brucella abortus serum, bovine[J].Chinese Journal of Biotechnology,2011,27(5):812-816. |
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| Authors: | Cui Li Fushi Guan Zhihong Dai Hui Jiang Fang Wen Lianshou Lu and Zaishi Wang |
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| Institution: | State Key Laboratory of Pathogen and Biosecurity, Beijing Institute of Microbiology and Epidemiology, Beijing 100071, China;State Key Laboratory of Pathogen and Biosecurity, Beijing Institute of Microbiology and Epidemiology, Beijing 100071, China;State Key Laboratory of Pathogen and Biosecurity, Beijing Institute of Microbiology and Epidemiology, Beijing 100071, China;State Key Laboratory of Pathogen and Biosecurity, Beijing Institute of Microbiology and Epidemiology, Beijing 100071, China |
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| Abstract: | To prepare anti-Brucella abortus serum used for calibrate the agglutination test follwing the national standard, 4 anti-Brucella abortus sera were obtained from 4 cows infected with Brucella abortus naturally. By potency testing, the third serum was selected. Sterility, vaccum degree, residual moisture, uniformity and stability of this standard material were tested and proved to meet the national standard. Referring to the international standard, RBT (Rose-Bengal plate agglutination test), SAT (standard tube agglutination) and CFT (complement fixation test) titers of this standard material were measured to be 1:160 "+" 1:2 400 "++" and 1:800 "++", which are identical with the collaborative assay results. International unit of the standard material is 4 000 IU/mL. |
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| Keywords: | enterovirus type 71 hand-foot-mouth disease (HFMD) intravenous immunoglobulin (IVIG) neutralization antibody |
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