| 血管生成素样蛋白家族表达调控及其在动物分子育种领域的现状分析 |
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| 引用本文： | 付玮玮,马云,陈宁博,李何,白跃宇.血管生成素样蛋白家族表达调控及其在动物分子育种领域的现状分析[J].生物工程学报,2015,31(11):1567-1578. |
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| 作者姓名： | 付玮玮 马云 陈宁博 李何 白跃宇 |
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| 作者单位： | 1 信阳师范学院生命科学学院，河南 信阳 464000,1 信阳师范学院生命科学学院，河南 信阳 464000,1 信阳师范学院生命科学学院，河南 信阳 464000,2 信阳职业技术学院应用化学与环境工程学院，河南 信阳 464000,3 河南省动物卫生监督所，河南 郑州 450008 |
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| 基金项目： | 国家自然科学基金 (No. 31172193), 河南省科技创新人才项目 (No. 134100510012), 河南省高校科技创新人才项目 (No. 2012HASTIT027), 河南省高校科技创新团队项目 (No. 14IRTSTHN012) 资助。 |
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| 摘 要： | 血管生成素样蛋白(Angiopoietin-like proteins,Angptls)是与脂类、葡萄糖、能量代谢和血管生成密切相关的蛋白质家族,现已发现8个成员,因其在代谢调控和动物辅助选育方面发挥有重要作用而备受研究人员的关注。以下综述了该蛋白家族的结构、介导的信号通路、上游调控基因及代谢网络等方面,并结合课题组研究工作对其应用于动物育种领域的现状和问题进行了分析,对前景作了展望。
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| 关 键 词： | 血管生成素样蛋白，结构，信号传导，功能，动物育种 |
| 收稿时间： | 2015/1/21 0:00:00 |
Expression of angiopoietin-like proteins for animal breeding: a review |
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| Weiwei Fu,Yun M,Ningbo Chen,He Li and Yueyu Bai.Expression of angiopoietin-like proteins for animal breeding: a review[J].Chinese Journal of Biotechnology,2015,31(11):1567-1578. |
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| Authors: | Weiwei Fu Yun M Ningbo Chen He Li and Yueyu Bai |
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| Institution: | 1 College of Life Sciences, Xinyang Normal University, Xinyang 464000, Henan, China,1 College of Life Sciences, Xinyang Normal University, Xinyang 464000, Henan, China,1 College of Life Sciences, Xinyang Normal University, Xinyang 464000, Henan, China,2 College of Applied Chemistry and Environmental Engineering, Xinyang Vocational and Technical College, Xinyang 464000, Henan, China and 3 Henan Institute of Animal Health Supervision, Zhengzhou 450008, Henan, China |
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| Abstract: | Angiopoietin-like proteins are a family of proteins that are closely related to lipid, glucose and energy metabolism, as well as angiogenesis. To date, eight Angptls have been discovered, namely Angptl1 to Angptl8 that play key roles in metabolic regulation and marker assisted selection. In this review, we summarized current progress on the structure, signaling pathways, upstream regulatory genes and metabolic network of Angptl1-8. Finally, in combination with our work, the status and problems of animal breeding as well as the future prospects for Angptls were discussed. |
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| Keywords: | Angiopoietin-like proteins (Angptls) structure signal transduction function animal breeding |
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