| 大肠杆菌生产异戊二烯的代谢工程研究进展 |
| |
| 引用本文： | 郭静,曹玉锦,咸漠,刘会洲.大肠杆菌生产异戊二烯的代谢工程研究进展[J].生物工程学报,2016,32(8):1026-1037. |
| |
| 作者姓名： | 郭静 曹玉锦 咸漠 刘会洲 |
| |
| 作者单位： | 1 中国科学院青岛生物能源与过程研究所 中国科学院生物基材料重点实验室，山东 青岛 266101；2 中国科学院大学，北京 100049,1 中国科学院青岛生物能源与过程研究所 中国科学院生物基材料重点实验室，山东 青岛 266101,1 中国科学院青岛生物能源与过程研究所 中国科学院生物基材料重点实验室，山东 青岛 266101,1 中国科学院青岛生物能源与过程研究所 中国科学院生物基材料重点实验室，山东 青岛 266101 |
| |
| 基金项目： | 国家自然科学基金 (No. 21572242)，泰山学者攀登计划 (No. TSPD20150210) 资助。 |
| |
| 摘 要： | 异戊二烯作为一种重要的化工原料,主要用于合成橡胶。此外,还广泛应用于医药或化工中间体、食品、粘合剂及航空燃料等领域。利用微生物法生产异戊二烯因具有环境友好、利用廉价的可再生原料、可持续发展等优势而成为当今研究的热点。这里介绍了大肠杆菌生产异戊二烯的代谢途径及关键酶,从代谢工程的角度出发综述了目前为提高大肠杆菌异戊二烯产量所应用到的方法和策略,并对今后的发展方向进行了展望。
|
| 关 键 词： | 异戊二烯，合成橡胶，大肠杆菌，代谢工程 |
| 收稿时间： | 2015/12/9 0:00:00 |
Advances in metabolic engineering of Escherichia coli for isoprene biosynthesis |
| |
| Jing Guo,Yujin Cao,Mo Xian and Huizhou Liu.Advances in metabolic engineering of Escherichia coli for isoprene biosynthesis[J].Chinese Journal of Biotechnology,2016,32(8):1026-1037. |
| |
| Authors: | Jing Guo Yujin Cao Mo Xian and Huizhou Liu |
| |
| Institution: | 1 CAS Key Laboratory of Biobased Materials, Qingdao Institute of Bioenergy and Bioprocess Technology, Chinese Academy of Sciences, Qingdao 266101, Shandong, China; 2 University of Chinese Academy of Sciences, Beijing 100049, China,1 CAS Key Laboratory of Biobased Materials, Qingdao Institute of Bioenergy and Bioprocess Technology, Chinese Academy of Sciences, Qingdao 266101, Shandong, China,1 CAS Key Laboratory of Biobased Materials, Qingdao Institute of Bioenergy and Bioprocess Technology, Chinese Academy of Sciences, Qingdao 266101, Shandong, China and 1 CAS Key Laboratory of Biobased Materials, Qingdao Institute of Bioenergy and Bioprocess Technology, Chinese Academy of Sciences, Qingdao 266101, Shandong, China |
| |
| Abstract: | As an important industrial chemical, isoprene is mainly used as a precursor for synthetic rubbers. In addition, it also has wide applications in the field of pharmaceutical and chemical intermediates, food, adhesives and aviation fuel. Compared with conventional petrochemical routes, production of isoprene in microbial systems has been the research focus considering environment friendly and sustainable development features. This article summarizes the metabolic pathways and key enzymes of isoprene biosynthesis, reviews current methods and strategies in improving isoprene production of Escherichia coli, and also gives some basic ideas and expectation. |
| |
| Keywords: | isoprene synthetic rubber Escherichia coli metabolic engineering |
| 本文献已被 CNKI 等数据库收录！ |
| 点击此处可从《生物工程学报》浏览原始摘要信息 |
| 点击此处可从《生物工程学报》下载免费的PDF全文 |
|
