| 微生物法生产1,3-二羟基丙酮代谢工程研究进展 |
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| 引用本文： | 孙丽慧,胡忠策,郑裕国,沈寅初.微生物法生产1,3-二羟基丙酮代谢工程研究进展[J].生物工程学报,2010,26(9):1218-1224. |
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| 作者姓名： | 孙丽慧 胡忠策 郑裕国 沈寅初 |
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| 作者单位： | 浙江工业大学生物工程研究所,杭州,310032 |
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| 基金项目： | 国家重点基础研究发展计划 (973计划) (No. 2007CB714306)，浙江省重大科技专项 (No. 2008C01014-2) 资助。 |
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| 摘 要： | 1,3-二羟基丙酮是一种重要的化工原料和医药中间体,广泛应用于化妆品、医药、食品等领域。以下综述了微生物法生产1,3-二羟基丙酮的代谢途径和关键酶,以及微生物法生产1,3-二羟基丙酮所涉及的代谢工程技术的研究进展。指出利用基因工程的方法对菌株进行改造,提高甘油脱氢酶催化活性,同时根据菌株的代谢特性,对发酵过程进行调控,提高1,3-二羟基丙酮的得率,是今后的研究方向。
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| 关 键 词： | 1 3-二羟基丙酮，代谢工程，发酵，甘油 |
| 收稿时间： | 2010/4/22 0:00:00 |
Progress in metabolic engineering of microbial production of 1,3-dihydroxyacetone |
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| Lihui Sun,Zhongce Hu,Yuguo Zheng and Yinchu Shen.Progress in metabolic engineering of microbial production of 1,3-dihydroxyacetone[J].Chinese Journal of Biotechnology,2010,26(9):1218-1224. |
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| Authors: | Lihui Sun Zhongce Hu Yuguo Zheng and Yinchu Shen |
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| Institution: | Institute of Bioengineering, Zhejiang University of Technology, Hangzhou 310032, China;Institute of Bioengineering, Zhejiang University of Technology, Hangzhou 310032, China;Institute of Bioengineering, Zhejiang University of Technology, Hangzhou 310032, China;Institute of Bioengineering, Zhejiang University of Technology, Hangzhou 310032, China |
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| Abstract: | 1,3-Dihydroxyacetone is widely used in cosmetics, medicines and food products. We reviewed the recent progress in metabolic pathways, key enzymes, as well as metabolic engineering for microbial production of 1,3-dihydroxyacetone. We addressed the research trend to increase yield of 1,3-dihydroxyacetone by improving the activity of glycerol dehydrogenase with genetic engineering, and regulating of fermentation process based on metabolic characteristic of the strain. |
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| Keywords: | 1 3-dihydroxyacetone metabolic engineering fermentation glycerol |
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