| 猪瘟DNA疫苗研究进展 |
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| 引用本文： | 李娜,孙元,仇华吉.猪瘟DNA疫苗研究进展[J].生物工程学报,2010,26(3):281-289. |
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| 作者姓名： | 李娜 孙元 仇华吉 |
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| 作者单位： | 中国农业科学院哈尔滨兽医研究所兽医生物技术国家重点实验室,哈尔滨,150001 |
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| 基金项目： | 国家高技术研究发展计划 (863计划) (No. 2006AA10A204) 资助。 |
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| 摘 要： | 自1990年DNA疫苗问世以来,已有许多研究者构建了不同类型的DNA疫苗。这些载体能诱发机体产生不同程度的特异性体液免疫和(或)细胞免疫。研究者们也在猪瘟DNA疫苗研究方面做出了很多努力并取得了一定的成果。以下从猪瘟DNA疫苗的构建和评价、佐剂在猪瘟DNA疫苗中的应用、猪瘟DNA疫苗与其他疫苗的联合应用以及目前猪瘟DNA疫苗存在的问题和解决途径等方面做了比较全面的阐述。
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| 关 键 词： | 猪瘟，DNA疫苗，甲病毒复制子载体疫苗 |
| 收稿时间： | 2009/11/18 0:00:00 |
Progress in DNA vaccines against classical swine fever: a review |
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| Na Li,Yuan Sun and Huaji Qiu.Progress in DNA vaccines against classical swine fever: a review[J].Chinese Journal of Biotechnology,2010,26(3):281-289. |
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| Authors: | Na Li Yuan Sun and Huaji Qiu |
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| Institution: | State Key Laboratory of Veterinary Biotechnology, Harbin Veterinary Research Institute, Chinese Academy of Agricultural Sciences, Harbin 150001, China;State Key Laboratory of Veterinary Biotechnology, Harbin Veterinary Research Institute, Chinese Academy of Agricultural Sciences, Harbin 150001, China;State Key Laboratory of Veterinary Biotechnology, Harbin Veterinary Research Institute, Chinese Academy of Agricultural Sciences, Harbin 150001, China |
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| Abstract: | In 1990, it was reported that the naked DNA encoding an antigen (so-called DNA vaccine) transduced directly into the muscle is able to induce immune responses just like antigen inoculation. Since then, a number of DNA vaccines against different diseases have been developed and shown to induce different levels of specific humoral and/or cell-mediated immunity. Efforts have been made to develop effective DNA vaccines against classical swine fever (CSF). This review covered the following aspects in the development and application of CSF DNA vaccines: construction and evaluation, application of adjuvants, combination with other vaccines and the existing problems and solutions. |
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| Keywords: | classical swine fever DNA vaccine alphaviral replicon vectored vaccine |
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