| 微生物发酵产二十二碳六烯酸代谢机理的研究进展 |
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| 引用本文： | 冯云,任路静,魏萍,仝倩倩,纪晓俊,黄和.微生物发酵产二十二碳六烯酸代谢机理的研究进展[J].生物工程学报,2010,26(9):1225-1231. |
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| 作者姓名： | 冯云 任路静 魏萍 仝倩倩 纪晓俊 黄和 |
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| 作者单位： | 南京工业大学生物与制药工程学院,材料化学工程重点实验室,南京,210009 |
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| 基金项目： | 国家自然科学基金重点项目 (No. 20936002)，国家重点基础研究发展计划 (973计划) (Nos. 2007CB707805, 2009CB724700)，江苏省六大人才高峰项目 (No. 2008-D-63)，江苏省高校科研成果产业化推进项目 (No. JH09-30) 资助。 |
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| 摘 要： | 二十二碳六烯酸(简称DHA)是一种重要的长链多不饱和脂肪酸,对人体具有重要的生理功能。微生物发酵生产的DHA与鱼油来源的DHA相比,具有诸多优点,其发展前景广阔。以下从发酵菌株、代谢途径、关键酶以及油脂积累机制等方面进行了综述,为通过代谢工程等技术手段进一步提高DHA产量提供了参考。
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| 关 键 词： | DHA，发酵，代谢途径，机理 |
| 收稿时间： | 5/9/2010 12:00:00 AM |
Progress in metabolic mechanism of docosahexenoic acid production by fermentation |
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| Yun Feng,Lujing Ren,Ping Wei,Qianqian Tong,Xiaojun Ji and He Huang.Progress in metabolic mechanism of docosahexenoic acid production by fermentation[J].Chinese Journal of Biotechnology,2010,26(9):1225-1231. |
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| Authors: | Yun Feng Lujing Ren Ping Wei Qianqian Tong Xiaojun Ji and He Huang |
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| Institution: | State Key Laboratory of Materials-Oriented Chemical Engineering, College of Biotechnology and Pharmaceutical Engineering, Nanjing University of Technology, Nanjing 210009, China;State Key Laboratory of Materials-Oriented Chemical Engineering, College of Biotechnology and Pharmaceutical Engineering, Nanjing University of Technology, Nanjing 210009, China;State Key Laboratory of Materials-Oriented Chemical Engineering, College of Biotechnology and Pharmaceutical Engineering, Nanjing University of Technology, Nanjing 210009, China;State Key Laboratory of Materials-Oriented Chemical Engineering, College of Biotechnology and Pharmaceutical Engineering, Nanjing University of Technology, Nanjing 210009, China;State Key Laboratory of Materials-Oriented Chemical Engineering, College of Biotechnology and Pharmaceutical Engineering, Nanjing University of Technology, Nanjing 210009, China;State Key Laboratory of Materials-Oriented Chemical Engineering, College of Biotechnology and Pharmaceutical Engineering, Nanjing University of Technology, Nanjing 210009, China |
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| Abstract: | Docosahexenoic acid (DHA) is an important polyunsaturated fatty acid which is beneficial to human health. Compared with the DHA derived from fish oil, DHA by microbial production possesses many advantages, and has a bright prospect. In this article, we reviewed strains, metabolic pathway, key enzymes and mechanism of lipid accumulation for microbial production of DHA. Those information would be greatly helpful for further improving DHA production by metabolic engineering. |
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| Keywords: | DHA fermentation metabolic pathway mechanism |
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