| 功能化量子点在肿瘤诊治中的应用 |
| |
| 引用本文： | 韩爽,夏天,李庆宁,郭俊明,陆佩蓓.功能化量子点在肿瘤诊治中的应用[J].生物工程学报,2013,29(1):10-20. |
| |
| 作者姓名： | 韩爽 夏天 李庆宁 郭俊明 陆佩蓓 |
| |
| 作者单位： | 1. 宁波大学医学院,浙江宁波,315211
2. 宁波卫生职业技术学院,浙江宁波,315010 |
| |
| 基金项目： | 国家自然科学基金 (No. 81201185)，浙江省教育厅基金 (No. Y201018152)，宁波市自然科学基金 (No. 2011A610027)，宁波大学学科项目 (Nos. B00121104700, xkl126, XYL10003, szxl1076)，宁波市科技创新团队项目(No. 2011B82014) 资助。 |
| |
| 摘 要： | 量子点是一种半导体纳米晶体,它可发出激发荧光,具有亮度高、稳定时间长和发射光谱可调节等特性,是同时检测多信号的良好材料.这些独特性质使得它们在肿瘤诊治领域中的应用日益受到人们的重视.对量子点进行功能化修饰,如偶联抗体等活性物质后,可以对肿瘤细胞进行特异性识别及示踪,以实现对肿瘤的诊断和治疗.文中分别从分子靶向识别、淋巴结定位和药物传递等方面探讨了功能化量子点在肿瘤诊断和治疗中的最新进展.此外,还讨论了量子点的毒性以及用于肿瘤检测和治疗的多功能量子点的设计方法,并提出了其实际应用的潜在方向.
|
| 关 键 词： | 纳米技术 量子点 肿瘤早期诊断 肿瘤治疗 毒性 |
| 收稿时间： | 2012/7/15 0:00:00 |
Application of functional quantum dots in cancer diagnosis and therapy: a review |
| |
| Shuang Han,Tian Xi,Qingning Li,Junming Guo and Peibei Lu.Application of functional quantum dots in cancer diagnosis and therapy: a review[J].Chinese Journal of Biotechnology,2013,29(1):10-20. |
| |
| Authors: | Shuang Han Tian Xi Qingning Li Junming Guo and Peibei Lu |
| |
| Institution: | Medical School, Ningbo University, Ningbo 315211, Zhejiang, China;Medical School, Ningbo University, Ningbo 315211, Zhejiang, China;Medical School, Ningbo University, Ningbo 315211, Zhejiang, China;Medical School, Ningbo University, Ningbo 315211, Zhejiang, China;Ningbo College of Health Science, Ningbo 315010, Zhejiang, China |
| |
| Abstract: | Quantum dots (QDs) are nanometer-sized luminescent semiconductor nanocrystals. Their unique optical properties, such as high brightness, long-term stability, simultaneous detection of multiple signals and tunable emission spectra, make them appealing as potential diagnostic and therapeutic systems in oncology. Preparing the functional QDs by modifying bio-molecules such as antibody will have potential value for cancer diagnosis and treatment. This paper summarized the recent progress of promising application of QDs in cancer diagnosis and therapy, from identifying molecular targets, to drug delivery and therapy; from limitations of toxicity issues related to QDs in living organisms to multifunctional design and development. Finally, the promising applications of QDs are also discussed. |
| |
| Keywords: | nanotechnology quantum dots (QDs) early diagnosis of tumor tumor therapy toxicity |
| 本文献已被 CNKI 万方数据 等数据库收录！ |
| 点击此处可从《生物工程学报》浏览原始摘要信息 |
| 点击此处可从《生物工程学报》下载免费的PDF全文 |
|
