Non-competitive product inhibition in lactic acid fermentation from glucose |
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| Authors: | Hitomi Ohara Keiichiro Hiyama Toshiomi Yoshida |
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| Institution: | (1) Central Research Laboratory, Shimadzu Co., 1 Nishinokyo-Kuwabaracho, Nakagyo-ku, 604 Kyoto, Japan;(2) Osaka Municipal Technical Research Institute, 1-6-50 Morinomiya, Joto-ku, 536 Osaka, Japan;(3) International Center of Cooperative Research in Biotechnology, Faculty of Engineering, Osaka University, 2-1 Yamadaoka, Suita-shi, 565 Osaka, Japan |
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| Abstract: | Summary A kinetic study regarding product inhibition in lactic acid fermentation by Streptococcus faecalis, which produces l-lactic acid, was performed in a chemostat at various feed concentrations of glucose (10, 20, and 30 g/l) at pH 7.0. Steady-state kinetic constants for the specific consumption rate of glucose and the specific production rate of lactic acid were determined at a residual glucose concentration below 2 g/l, which was accomplished in a chemostat. All the parameters, the specific growth rate, the specific consumption rate of glucose, and the specific production rate of lactic acid, were definitely related to non-competitive inhibition with regard to the concentration of the product, lactic acid.Offprint requests to: K. Hiyama |
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