The inhibitory effects of mushroom extracts on sucrose-dependent oral biofilm formation |
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| Authors: | Akira Yano Sayaka Kikuchi Yoshihisa Yamashita Yuichi Sakamoto Yuko Nakagawa Yasuo Yoshida |
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| Institution: | (1) Iwate Biotechnology Research Center, 22-174-4 Narita, Kitakami Iwate, 024-0003, Japan;(2) Department of Preventive Dentistry, Kyushu University Faculty of Dentistal Science, 3-1-1 Maidashi, Higashi-ku Fukuoka, 812-8582, Japan;(3) Department of Dental Pharmacology, Iwate Medical University School of Dentistry, 1-3-27 Chuo-dori, Morioka Iwate, 020-8505, Japan |
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| Abstract: | Mushrooms contain large quantities of α-glucans. Shiitake (Lentinula edodes), Japan’s most popular edible mushroom, has been reported to contain about 6% (weight/dried weight) of α-(1,3)-glucan. This
glucan is one of the major components of oral biofilm formed by the cariogenic bacteria Streptococcus mutans and Streptococcus sobrinus. We found that extracts from shiitake and other edible mushrooms could reduce preformed biofilms of S. mutans and S. sobrinus in the presence of dextranase. We also investigated the α-glucanase activities of shiitake mushroom extracts and their effects
on biofilm formation. The extracts possessed α-glucanase activity and degraded water-insoluble glucans from mutans streptococci.
The extracts strongly inhibited the sucrose-dependent formation of biofilms by S. mutans and S. sobrinus in the presence of dextranase. Our results suggest that some components of mushrooms, including α-glucanases, might inhibit
the sucrose-induced formation of oral biofilms. |
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