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Recent advances in biotechnological applications of alcohol dehydrogenases |
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| Authors: | Zheng Yu-Guo Yin Huan-Huan Yu Dao-Fu Chen Xiang Tang Xiao-Ling Zhang Xiao-Jian Xue Ya-Ping Wang Ya-Jun Liu Zhi-Qiang |
| Institution: | 1.Key Laboratory of Bioorganic Synthesis of Zhejiang Province, College of Biotechnology and Bioengineering, Zhejiang University of Technology, Hangzhou, 310014, People’s Republic of China ; |
| Abstract: | Alcohol dehydrogenases (ADHs), which belong to the oxidoreductase superfamily, catalyze the interconversion between alcohols and aldehydes or ketones with high stereoselectivity under mild conditions. ADHs are widely employed as biocatalysts for the dynamic kinetic resolution of racemic substrates and for the preparation of enantiomerically pure chemicals. This review provides an overview of biotechnological applications for ADHs in the production of chiral pharmaceuticals and fine chemicals. |
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