Achievements and impacts of glycosylation reactions involved in natural product biosynthesis in prokaryotes |
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Authors: | Myoung Chong Song Eunji Kim Yeon Hee Ban Young Ji Yoo Eun Ji Kim Sung Ryeol Park Ramesh Prasad Pandey Jae Kyung Sohng Yeo Joon Yoon |
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Institution: | 1. Department of Chemistry and Nano Science, Ewha Womans University, Seoul, 120-750, Republic of Korea 3. Intelligent Synthetic Biology Center, KAIST, Daejeon, 305-701, Republic of Korea 2. Institute of Biomolecule Reconstruction (IBR), Department of Pharmaceutical Engineering, Sun Moon University, Asan, 336-708, Republic of Korea
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Abstract: | Bioactive natural products, such as polyketides, flavonoids, glycopeptides, and aminoglycosides, have been used as therapeutic agents. Many of them contain structurally diverse sugar moieties attached to the aglycone core structures. Glycosyltransferases (GTs) catalyze the attachment of nucleotide-activated sugar substrates to acceptor aglycones. Because these sugar moieties are usually essential for biological activity, in vivo pathway engineering in prokaryotic hosts and in vitro enzymatic approaches coupled with GT engineering are currently being used to synthesize novel glycosylated derivatives, and some of them exhibited improved biological activities compared to the parent molecules. Therefore, harnessing the potential of diverse glycosylation reactions in prokaryotes will increase the structural diversity of natural products and the possibility to generate new bioactive products. |
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