A review: recent advances and future prospects of taxol-producing endophytic fungi |
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Authors: | Xuanwei Zhou Huifang Zhu Lu Liu Juan Lin Kexuan Tang |
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Institution: | (1) Plant Biotechnology Research Center, School of Agriculture and Biology, Fudan–SJTU–Nottingham Plant Biotechnology R&D Center, Shanghai Jiao Tong University, Shanghai, 200240, People’s Republic of China;(2) State Key Laboratory of Genetic Engineering, School of Life Sciences, Morgan–Tan International Center for Life Sciences, Fudan–SJTU–Nottingham Plant Biotechnology R&D Center, Fudan University, Shanghai, People’s Republic of China |
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Abstract: | In the urgent search for more effective ways to treat cancer, new extraction methods of taxol from endophytic fungus have
demonstrated high potential in increasing the efficiency of taxol extraction for more efficient and sustainable production
of taxol and cancer treatment products. This paper summarizes recent advances in taxol-producing endophytic fungi, both in
China and abroad, in the following areas: isolation and identification of endophytic fungi types, extraction and detection
methods of endophytic taxol in plants, and improved efficiency of the extraction process. With the advancement of science
and technology, new techniques in biotechnology, such as fungal strain improvement and recombining technique and microbial
fermentation engineering, have increased the extraction yield from taxol-producing fungi, thereby improved the overall efficiency
of taxol production. |
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