Metabolic engineering of <Emphasis Type="Italic">Escherichia coli</Emphasis> for biotechnological production of high-value organic acids and alcohols |
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Authors: | Chao Yu Yujin Cao Huibin Zou Mo Xian |
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Institution: | (1) Key Lab of Biofuels, Qingdao Institute of Bioenergy and Bioprocess Technology, Chinese Academy of Sciences, 266101 Qingdao, China; |
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Abstract: | Confronted with the gradual and inescapable exhaustion of the earth’s fossil energy resources, the bio-based process to produce
platform chemicals from renewable carbohydrates is attracting growing interest. Escherichia coli has been chosen as a workhouse for the production of many valuable chemicals due to its clear genetic background, convenient
to be genetically modified and good growth properties with low nutrient requirements. Rational strain development of E. coli achieved by metabolic engineering strategies has provided new processes for efficiently biotechnological production of various
high-value chemical building blocks. Compared to previous reviews, this review focuses on recent advances in metabolic engineering
of the industrial model bacteria E. coli that lead to efficient recombinant biocatalysts for the production of high-value organic acids like succinic acid, lactic
acid, 3-hydroxypropanoic acid and glucaric acid as well as alcohols like 1,3-propanediol, xylitol, mannitol, and glycerol
with the discussion of the future research in this area. Besides, this review also discusses several platform chemicals, including
fumaric acid, aspartic acid, glutamic acid, sorbitol, itaconic acid, and 2,5-furan dicarboxylic acid, which have not been
produced by E. coli until now. |
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