Prospects for a bio-based succinate industry |
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| Authors: | James B McKinlay C Vieille J Gregory Zeikus |
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| Institution: | (1) Department of Microbiology and Molecular Genetics, Michigan State University, East Lansing, MI 48824, USA;(2) Department of Biochemistry and Molecular Biology, Michigan State University, 410 Biochemistry Building, East Lansing, MI 48824, USA |
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| Abstract: | Bio-based succinate is receiving increasing attention as a potential intermediary feedstock for replacing a large petrochemical-based
bulk chemical market. The prospective economical and environmental benefits of a bio-based succinate industry have motivated
research and development of succinate-producing organisms. Bio-based succinate is still faced with the challenge of becoming
cost competitive against petrochemical-based alternatives. High succinate concentrations must be produced at high rates, with
little or no by-products to most efficiently use substrates and to simplify purification procedures. Herein are described
the current prospects for a bio-based succinate industry, with emphasis on specific bacteria that show the greatest promise
for industrial succinate production. The succinate-producing characteristics and the metabolic pathway used by each bacterial
species are described, and the advantages and disadvantages of each bacterial system are discussed. |
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| Keywords: | Bio-based succinate 1 4-Butanediol Metabolic engineering Escherichia coli Actinobacillus succinogenes Mannheimia succiniciproducens |
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