中药提取液对灵芝深层发酵的影响

我国中医药历史悠久 ,中药资源丰富 ,为保证广大人们的身体健康起到巨大作用。但近几十年来 ,我国在中药现代化方面进展缓慢 ,其中原因之一就是中药加工技术陈旧1] ,近来有学者提出了中药发酵制药技术1,2 ] 。药用真菌是中药的组成部分 ,它们中的许多种类都能以液体发酵进行生产3] ,以适当的中药为培养基或在培养基中添加适量的中药 ,利用它们强大的分解转化能力 ,不仅可对中药中的纤维、糖类和蛋白等物质加以利用 ,而且在代谢过程中可能对中药中的一些成分进行转化 ,从而提高中药活性成分在复合制剂中的比例及效价 ;另外中药中的某些成…

Effects of Extracts of Chinese Medicines on Ganoderma lucidum in Submerged Culture

Effects of water and ethanol extracts of 10 Chinese medicines, such as Astragalus membranaceus, Coix lachryma-jobi, etc ., on biomass and exopolysaccharide of Ganoderma lucidum were studied by submerged culture. The results showed: water extracts of all medicines can improve the culture of G. lucidum except of A. membranaceus , ethanol extracts of C. lachryma-jobi, Dioscorea opposita, Codonopsis pilosula , and Achyranthes bidentata (<187.5g Medicine/L substrate) can also increase the biomass of G. lucidum , but the ethanol extracts of Angelica sinensis, Dendrobium nobile check the growth of G. lucidum. The production of exopolysa- ccharide can be improved by all the Chinese medicines and their dosage used in this experiment, Although A. sinensis, D. Nobile check the growth of G. lucidum , they could stimulate the secretion of exopolysa- ccharide in lower dosage. It is concluded that some Chinese medicines, such as C. lachryma-jobi, D. opposita, C. pilosula, etc. can be processed by the fermentation of G. lucidum, and bio-active compound can be produced by adding appropriate Chinese medicine in the substrate to culture G. lucidum.