纤维堆囊菌的供谢产物及其生物学活性分析

纤维堆囊菌不同菌株不但表现细胞和子实体形态的差异，而且供谢产物的组成和生物学活性也存在差异。纤维堆囊菌对革兰氏阴性细菌不表现任何抑制活性，部分菌株可抑制革兰氏阳性细菌；但所有菌株对真菌和肿瘤细胞有广泛和强烈的抑制作用。薄层层析显示，纤维堆囊菌的次级代谢产物组分较多，且大多数组分具有不同程度的抑制真菌和肿细胞的活性。在筛选中发现四株菌的代谢产物能够促进微管蛋白聚合，其中So33-1活性组分的薄层层析Rf值与已知的Epothilone A相似，而So81的则有较大的差异。研究结果表明纤维堆囊菌是很好的筛选抗真核生物活性的天然化合物资源。

DIVERSITY OF METABOLITES AND THEIR BIO-ACTIVITIES IN MYXOBACTERIUM SORANGIUM CELLULOSUM

Different Sorangium cellulosum strains not only showed diversity in their cell and fruiting body morphologies, but also differences of bio-activities and components of the metabolites. All the Sorangial strains studied in this paper had no activity on Gram-negative bacteria, some were able to repress Gram-positive bacteria. However, all the strains were able to repress growth of fungi and tumor cells strongly and widely. Thin layer chromatography assay of metabolites showed multi-components in the metabolites, and most of them have abilities of repressing fungi and tumor cells in different degrees. Four strains were found to be able to produce compounds with activity of promoting polymerization of microtubule. Based on R-f value on TLC, the bio-active component produced by So33-1 strain was similar to Epothilone A, while that of So81 was much different. The results of this paper suggested that Sorangium cellulosum is a much beneficial resource for screening nature compounds with bio-activities against eukaryotes.