| 糖苷水解酶——生物转化制备活性糖苷与苷元的有效工具 |
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| 引用本文： | 原野,胡彦波,周义发.糖苷水解酶——生物转化制备活性糖苷与苷元的有效工具[J].微生物学报,2017,57(8):1219-1234. |
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| 作者姓名： | 原野 胡彦波 周义发 |
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| 作者单位： | 东北师范大学生命科学学院, 吉林 长春 130024,东北师范大学生命科学学院, 吉林 长春 130024,东北师范大学生命科学学院, 吉林 长春 130024 |
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| 基金项目： | 吉林省自然科学基金（20160101343JC） |
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| 摘 要： | 糖苷广泛存在于自然界,具有多种药理活性,是人类发现与生产药物的重要来源。糖苷中糖链部分的组成与其药理活性密切相关,改变糖苷分子中的糖链结构能改变糖苷的药理活性,为开发药物提供更多的化合物资源。糖苷水解酶修饰糖链具有效率高、成本低、污染小等优点,被广泛应用于活性糖苷与苷元的制备。本文系统地总结了糖苷水解酶转化制备活性糖苷与苷元的研究进展,为研究糖苷酶生物转化制备活性化合物提供数据资源,为相关的研究和生产提供有用的文献资料。
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| 关 键 词： | 糖苷 糖苷水解酶 生物转化 |
| 收稿时间： | 2017/3/31 0:00:00 |
| 修稿时间： | 2017/5/27 0:00:00 |
Glycosidase:An effective tool for the preparation of active glycosides and aglycone |
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| Ye Yuan,Yanbo Hu and Yifa Zhou.Glycosidase:An effective tool for the preparation of active glycosides and aglycone[J].Acta Microbiologica Sinica,2017,57(8):1219-1234. |
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| Authors: | Ye Yuan Yanbo Hu and Yifa Zhou |
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| Institution: | School of Life Sciences, Northeast Normal University, Changchun 130024, Jilin Province, China,School of Life Sciences, Northeast Normal University, Changchun 130024, Jilin Province, China and School of Life Sciences, Northeast Normal University, Changchun 130024, Jilin Province, China |
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| Abstract: | Glycosides widely distributed in nature have many pharmacological activities. A lot of drugs belong to glycoside and the sugar chains are closely related to its pharmacological activities. The modification of sugar chains can change the pharmacological activities of glycosides, which provides tremendous glycoside resource for drug development. Because of high efficiency and low pollution, biotransformation by glycosidase is widely used in the preparation of active glycosides. This review summarized recent advances in the preparation of active glycosides by glycosidase transformation, and provided useful references for preparing active glycosides and related research work. |
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| Keywords: | glycosides glycosidase biotransformation |
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