| 产生坑肿瘤生素Sandramycin的南极放线菌C3905 |
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| 引用本文： | 胡继兰,张春颖.产生坑肿瘤生素Sandramycin的南极放线菌C3905[J].微生物学报,2000,40(6):646-651. |
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| 作者姓名： | 胡继兰 张春颖 |
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| 作者单位： | [1]中国医学科学院,北京 [2]中国协和医科大学医药生物技术研究所,北京 |
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| 基金项目： | 国家自然科学基金资助(39270012) |
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| 摘 要： | 从南极乔治王岛土壤分离到一株诺卡氏菌形放线菌Ｃ３９０５菌株。其气生菌丝白色，其内菌丝无色至乳脂或浅粉；菌丝直径０．５～０．８μｍ，断裂为杆状和球状体，表面光滑。胞壁化学Ｉ型；无枝菌酸；磷酸类酯ＰＩ型；优势甲基萘酯为ＭＫ－９（Ｈ４）。ＤＮＡ中Ｇ＋Ｃ含量为６８．３～６８．９ｍｏｌ％。兼性嗜冷，生长适温为１５℃～２０℃。产生抗肿瘤抗生素ｓａｎｄｒａｍｙｃｉｎ。基于以上特征及分子遗传分类的研究结果，我们建
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| 关 键 词： | 白色害诺卡氏菌南极变种 抗瘤 放线菌 抗生素 |
| 文章编号： | 0001-6209(2000)06-0646-51 |
| 修稿时间： | 1999年9月6日 |
A ACTINOMYCETE STRAIN
C3905PRODUCING ANTITUMOR ANTIBIOTIC SANDRAMYCIN FROM ANTARCTICA |
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| Hu Jilan.A ACTINOMYCETE STRAIN
C3905PRODUCING ANTITUMOR ANTIBIOTIC SANDRAMYCIN FROM ANTARCTICA[J].Acta Microbiologica Sinica,2000,40(6):646-651. |
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| Authors: | Hu Jilan |
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| Institution: | Institute of Medicinal Biotechnology, Chinese Academy of Medical Sciences, Peking Union Medical College, Beijing 100050. |
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| Abstract: | A nocardioform actinomycete strain C3905 was isolated from a soil sample collected in King Geoge island, Antarctica. Its aerial mycelium is white, substrate mycelium is colorless to cream or pink. The hyphae of mycelium 0.5 micron-0.8 micron in diameter and they fragment into irregular rod to coccoid elements with smooth surface. Cell wall type I. The mycolic acids are lacking. Mk-9(H4) is the predominant menaquinone component. Phospholipid type PI. The G + C content of DNA is 68.3-68.9 mol%. Facultative psychrophile. The optimum temperature for growth is 15 degrees C-20 degrees C. Produces antitumor antibiotic sandramycin. Based on the characteristics above as well as the investigation of the molecular genetics. We propose that strain C3905 should be placed in the Nocardioides albus as a variant, named Nocardioides albus var. antarcticus. |
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| Keywords: | Nocardioides albus var antarcticus Sandramycin Antitumor Facultative psychrophile |
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