肠道菌群与帕金森病的相关性研究

人体内肠道菌群数量庞大,参与机体物质与能量代谢,对机体的生理活动具有重要调节作用。近年来,众多研究表明,肠道菌群稳态在维持大脑和神经系统的正常功能中发挥着重要作用,肠道菌群失调与帕金森病(Parkinson’s disease,PD)等神经疾病的发作密切相关。目前,针对PD发病机制与肠道菌群失调的研究成果丰富,表明肠道菌群在PD发病中起着重要的诱导作用。本文梳理了肠道菌群紊乱与PD发生的相关国内外文献,通过深入分析PD患者肠道菌群的变化特征,讨论了PD与肠道菌群变化间的关系;同时,探讨了粪便移植技术在PD治疗中的应用,旨在为有效预防与治疗PD提供可靠的理论依据。

Correlation of gut microbiota with Parkinson's disease

The large number of gut microbiota (GM) in human body, participating in the material metabolize and energy cycles, regulates the physiological activities of the body. In recent years, many studies demonstrate that the stable state of GM plays an essential role in maintaining the normal function of the brain and nervous system. GM disorder is closely related to some neurological diseases like Parkinson''s disease (PD). At present, there are abundant research results on relationship between the pathogenesis of PD and the dysregulation of GM, indicating that GM brings a vital induction effect to the pathogenesis of PD. After reviewing the literature on the correlation of GM with PD and analyzing the change of GM in PD patients, we discuss the relationship between the occurrence of PD and the change of GM. Moreover, we also address the application of faecal transplants treatment in PD treatment in order to provide a reliable theoretical basis for the potential prevention and treatment of PD by regulating GM.