| 白念珠菌钙稳态系统及钙信号途径的研究进展 |
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| 引用本文： | 喻其林,徐宁,李明春.白念珠菌钙稳态系统及钙信号途径的研究进展[J].微生物学报,2012,52(4):422-428. |
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| 作者姓名： | 喻其林 徐宁 李明春 |
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| 作者单位： | 南开大学微生物学系，分子微生物学与技术教育部重点实验室，天津300071;南开大学微生物学系，分子微生物学与技术教育部重点实验室，天津300071;南开大学微生物学系，分子微生物学与技术教育部重点实验室，天津300071 |
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| 基金项目： | 国家自然科学基金(81171541，31070126);天津市应用基础及前沿技术研究计划(10JCYBJC09700) |
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| 摘 要： | 白念珠菌是临床重要的条件致病菌,其胞内的钙稳态及钙信号途径与宿主侵染、压力应答等诸多生理过程紧密相关。研究该菌的钙稳态系统及钙信号调控网络,对明确白念珠菌的侵染机制与耐药机理,以及开发具有新靶点的抗真菌药物具有重要意义。本文对这些内容的研究进展进行了综述。
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| 关 键 词： | 白念珠菌 钙稳态 钙信号途径 压力应答 |
| 收稿时间： | 2011/10/1 0:00:00 |
| 修稿时间： | 2011/11/18 0:00:00 |
Calcium homeostasis systems and calcium signaling pathways in Candida albicans--a review |
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| Qilin Yu,Ning Xu and Mingchun Li.Calcium homeostasis systems and calcium signaling pathways in Candida albicans--a review[J].Acta Microbiologica Sinica,2012,52(4):422-428. |
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| Authors: | Qilin Yu Ning Xu and Mingchun Li |
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| Institution: | Key Laboratory of Molecular and Technology, Ministry of Education, Department of Microbiology, Nankai University, Tianjin 300071, China. yuqilin7007@163.com |
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| Abstract: | Candida albicans is one of the most important conditional pathogens. Calcium homeostasis systems and calcium signaling in this pathogen are closely associated with numerous physiological processes, such as pathogenesis and stress responses. Study on calcium homeostasis systems and calcium signaling pathways will illuminate its calcium-related mechanisms of pathogenesis and drug resistance, and establish new therapeutic strategies for fungal infections. This review introduced the advances in the study in these fields. |
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| Keywords: | Candida albicans calcium homeostasis calcium signaling pathway stress response |
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