| RIG-I样受体与RNA病毒识别 |
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| 引用本文： | 秦成峰,秦鄂德.RIG-I样受体与RNA病毒识别[J].微生物学报,2008,48(10):1418-1423. |
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| 作者姓名： | 秦成峰 秦鄂德 |
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| 作者单位： | 病原微生物生物安全国家重点实验室,军事医学科学院微生物流行病研究所,北京,100071 |
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| 基金项目： | 国家自然科学基金，国家重点基础研究发展计划(973计划) |
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| 摘 要： | RIG-I样受体(RIG-I like receptors,RLR)是一类新发现的模式识别受体,能够识别细胞质中的病毒RNA,通过RLR级联信号诱导干扰素和促炎症细胞因子的产生,对抗病毒天然免疫的建立起着非常重要的作用.RLR信号通路既受宿主的严格调控,也能够作为病毒逃避宿主干扰素反应的靶点.本文重点讨论了RLR及其在RNA病毒识别和抗病毒天然免疫中的作用.
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| 关 键 词： | 天然免疫 RNA病毒 干扰素 |
Retinoic acid-inducible gene-I-like receptors and RNA virus recognition——A review |
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| Chengfeng Qin and Ede Qin.Retinoic acid-inducible gene-I-like receptors and RNA virus recognition——A review[J].Acta Microbiologica Sinica,2008,48(10):1418-1423. |
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| Authors: | Chengfeng Qin and Ede Qin |
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| Institution: | State Key Laboratory of Pathogen and Biosecurity, Beijing Institute of Microbiology and Epidemiology, Beijing 100071, China;State Key Laboratory of Pathogen and Biosecurity, Beijing Institute of Microbiology and Epidemiology, Beijing 100071, China |
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| Abstract: | Retinoic acid-inducible gene I (RIG-I)-like receptors (RLRs) have recently been identified as cytoplasmic sensors for RNA viruses. The RLR signaling cascades induce the production of type I interferons and pro-inflammatory cytokines, which are rigorously regulated by the host. On other side, RNA viruses have evolved strategies to evade RLR signaling. In this review, we present our current understanding of RLR signaling in RNA virus recognition and antiviral innate immunity. |
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| Keywords: | RIG-I MDA5 RLR |
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