| 铜绿假单胞菌Ⅲ型分泌系统的分子调控机制 |
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| 引用本文： | 罗勤,金守光.铜绿假单胞菌Ⅲ型分泌系统的分子调控机制[J].微生物学报,2008,48(10):1413-1417. |
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| 作者姓名： | 罗勤 金守光 |
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| 作者单位： | 1. 遗传调控与整合生物学湖北省重点实验室,华中师范大学生命科学学院,武汉,430079
2. Departraent of Molecular Genetics and Microbiology,PO Box 100266,University of Florida,Gainesville,FL 32610,USA |
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| 基金项目： | 国家自然科学基金，教育部留学回国人员科研启动基金，教育部211重点学科项目 |
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| 摘 要： | 铜绿假单胞菌是临床上重要的革兰氏阴性条件致病菌.通过Ⅲ型分泌系统,铜绿假单胞菌将其毒力因子注入到真核宿主细胞内部,逃避宿主巨噬细胞的吞噬降解,引起宿主相应的病理变化,是铜绿假单胞菌感染致病的重要原因.本文在简单介绍铜绿假单胞菌Ⅲ型分泌系统组成和功能的基础上,主要对调控T3SS基因转录表达的分子机制的研究进展进行综述和讨论.
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| 关 键 词： | 铜绿假单胞菌 Ⅲ型分泌系统 转录调控 |
Molecular determinants in regulating Pseudomonas aeruginosa type Ⅲ secretion system——A review |
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| Qin Luo and Shouguang Jin.Molecular determinants in regulating Pseudomonas aeruginosa type Ⅲ secretion system——A review[J].Acta Microbiologica Sinica,2008,48(10):1413-1417. |
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| Authors: | Qin Luo and Shouguang Jin |
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| Institution: | Hubei Key Laboratory of Genetic Regulation and Integrative Biology, College of Life Science, Central China Normal University, Wuhan 430079, China;Department of Molecular Genetics and Microbiology, PO Box 100266, University of Florida, Gainesville, FL 32610, USA |
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| Abstract: | Pseudomonas aeruginosa is a Gram-negative opportunistic bacterial pathogen. Successful injection of virulence factors into host cells, evasion of phagocytosis and promotion of pathogenesis depend primarily on the function of type III secretion system (T3SS). A complex set of signaling pathways have been shown to modulate T3SS expression. In this review, a brief introduction is given on the composition, function, and molecular determinants that regulate P. aeruginosa T3SS gene expression. |
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