| 单核细胞增生李斯特菌PrfA蛋白转录调控毒力基因表达的分子机制 |
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| 引用本文： | 罗 勤,张晓莉,李 兵,冯爱平,钱 跃.单核细胞增生李斯特菌PrfA蛋白转录调控毒力基因表达的分子机制[J].微生物学报,2008,35(2):0275-0280. |
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| 作者姓名： | 罗 勤 张晓莉 李 兵 冯爱平 钱 跃 |
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| 作者单位： | 华中师范大学生命科学学院 武汉 430079;华中师范大学生命科学学院 武汉 430079;华中师范大学生命科学学院 武汉 430079;华中科技大学附属协和医院皮肤科 武汉 430022;华中科技大学附属协和医院皮肤科 武汉 430022 |
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| 基金项目： | 国家自然科学基金项目(No.30500025); 教育部211重点学科项目资助 |
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| 摘 要： | 单核细胞增生李斯特菌 (Listeria monocytogenes LM) 属于典型的细胞内寄生革兰氏阳性菌, 是WHO公布的四大食源性致病菌之一。LM不仅是人畜共患传染病李斯特菌病 (listeriosis) 的主要病原菌, 也是研究胞内感染和细胞介导的免疫应答的模式细菌。绝大多数LM毒力基因的转录表达受到PrfA蛋白的调控。本文简单介绍了LM侵染宿主细胞必需的毒力基因及其产物; 重点对毒力基因调节蛋白PrfA的结构和功能, PrfA调节毒力基因表达的主要方式最新进展进行了综述和讨论。
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| 关 键 词： | 单核细胞增生李斯特菌 PrfA蛋白 毒力基因 表达调控 |
Regulation of PrfA-dependent Virulence Genes Expression in Listeria monocytogenes |
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| LUO Qin,ZHANG Xiao-Li,LI Bing,FENG Ai-Ping and QIAN Yue.Regulation of PrfA-dependent Virulence Genes Expression in Listeria monocytogenes[J].Acta Microbiologica Sinica,2008,35(2):0275-0280. |
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| Authors: | LUO Qin ZHANG Xiao-Li LI Bing FENG Ai-Ping and QIAN Yue |
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| Institution: | College of Life Science, Central China Normal University, Wuhan 430079;College of Life Science, Central China Normal University, Wuhan 430079;College of Life Science, Central China Normal University, Wuhan 430079;Department of Dermatology, Union Hospital Tongji Medical College, Huazhong University of Science and Technology, Wuhan 430022;Department of Dermatology, Union Hospital Tongji Medical College, Huazhong University of Science and Technology, Wuhan 430022 |
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| Abstract: | The gram-positive, facultative intracellular bacterium Listeria monocytogenes belongs to one of four severe food-borne pathogens issued by WHO. It is not only a causal agent of listeriosis caused infection of humans and animals, but also an important model system for the study of intracellular pathogens. Most of well-known listerial virulence genes are regulated by PrfA. The LM virulence genes involved in the infectious process and the PrfA-dependent virulence genes expression as well as putative regulative mechanisms were introduced and analyzed in this paper. |
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| Keywords: | Listeria monocytogenes PrfA Virulence gene Regulation |
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