| 转化石胆酸为熊去氧胆酸的菌种筛选和产物鉴定 |
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| 引用本文： | 孙黎,法幼华.转化石胆酸为熊去氧胆酸的菌种筛选和产物鉴定[J].微生物学报,1995,35(3):197-203. |
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| 作者姓名： | 孙黎 法幼华 |
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| 作者单位： | 中国科学院微生物研究所；中国科学院微生物研究所 北京 |
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| 摘 要： | 筛选到一株泡木贼镰刀菌(Fusarium equiseti)90-9菌株,它能转化石胆酸(Lithocholic acid)为熊去氧胆酸(Ursodeoxycholic acid).该菌转化0.1%(W/V)石胆酸96h,熊去氧胆酸重量收率为38.1%.经各项理化性质,包括熔点、比旋值、红外光谱、核磁共振谱、质谱和元素分析等项鉴定,证明产物为熊去氧胆酸.
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| 关 键 词： | 石胆酸 熊去氧胆酸 泡木贼镰刀菌 菌种 Lithocholic acid Ursodeoxycholic acid Fusarium equtseti |
SCREENING OF STRAINS PRODUCING URSODEOXYCHOLIC ACID FROM LITHOCHOLIC ACID AND IDENTIFICATION OF PRODUCT |
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| Sun Li Fa Youhua.SCREENING OF STRAINS PRODUCING URSODEOXYCHOLIC ACID FROM LITHOCHOLIC ACID AND IDENTIFICATION OF PRODUCT[J].Acta Microbiologica Sinica,1995,35(3):197-203. |
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| Authors: | Sun Li Fa Youhua |
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| Abstract: | Fusarium equiseti 90-9 was screened for microbial production ofursodeoxycholic acid from lithocholic acid. The weight yield was 38.1% in the presenceof 0.1% lithocholic acid (W/V) within 96h of cultivation. Determination of severalphysical-chemical characteristics including melting point, specific rotation, infraredabsorption spectrum, nuclear magnetic resonance, mass spectrum and elementcomposition etc indicated that the main product was ursodeoxycholic acid. |
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| Keywords: | Lithocholic acid Ursodeoxycholic acid Fusarium equtseti |
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