| 信号识别颗粒(SRP)在膜蛋白定位中的作用 |
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| 引用本文： | 赵留群,张大伟.信号识别颗粒(SRP)在膜蛋白定位中的作用[J].微生物学报,2022,62(12):4769-4780. |
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| 作者姓名： | 赵留群 张大伟 |
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| 作者单位： | 中国科学院天津工业生物技术研究所, 天津 300308;中国科学院天津工业生物技术研究所, 天津 300308;中国科学院大学, 北京 100049 |
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| 基金项目： | 天津市合成生物技术创新能力提升行动项目(TSBICIP-CXRC-055) |
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| 摘 要： | 依赖信号识别颗粒(signal recognition particle，SRP)的共翻译转运是所有生命体中的一个保守途径，它将新生肽链的翻译与转运耦联在一起。超过30%的新合成的多肽链被SRP转运到正确位置。最近的研究表明，大肠杆菌中SRP抑制子可以规避SRP的需求。当SRP缺失时，翻译控制在介导膜蛋白定位方面起着关键作用。本综述总结了SRP底物如何在存在或缺失SRP的情况下转运到适当的位置以及翻译速率降低如何补偿SRP的缺失。我们还讨论了不同蛋白质对SRP的依赖程度。这一回顾将为进一步研究SRP功能及膜蛋白定位提供新思路。
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| 关 键 词： | 信号肽识别颗粒 翻译调控 膜蛋白 共翻译转运途径 |
| 收稿时间： | 2022/4/3 0:00:00 |
| 修稿时间： | 2022/7/16 0:00:00 |
Role of signal recognition particle in membrane protein targeting |
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| ZHAO Liuqun,ZHANG Dawei.Role of signal recognition particle in membrane protein targeting[J].Acta Microbiologica Sinica,2022,62(12):4769-4780. |
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| Authors: | ZHAO Liuqun ZHANG Dawei |
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| Institution: | Tianjin Institute of Industrial Biotechnology, Chinese Academy of Sciences, Tianjin 300308, China; Tianjin Institute of Industrial Biotechnology, Chinese Academy of Sciences, Tianjin 300308, China;University of Chinese Academy of Sciences, Beijing 100049, China |
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| Abstract: | Signal recognition particle (SRP)-dependent co-translational protein targeting is a conserved pathway across all kingdoms of life. It couples the translation and translocation of nascent peptides. Over 30% of newly synthesized peptides are delivered to the correct localization by SRP. Recent studies have demonstrated that SRP suppressors can circumvent the SRP requirement in Escherichia coli. The translational control plays a critical role in mediating membrane protein targeting when SRP is absent. This review summarizes how the substrates of SRP translocate to the proper localization with or without SRP, and how the decreased translation rate compensates for the loss of SRP. Furthermore, we discuss the dependence of different proteins on SRP. This review will provide new ideas for further studies about the function of SRP and membrane protein targeting. |
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| Keywords: | signal recognition particle translational control membrane proteins co-translational protein targeting pathway |
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