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| 微生物来源的二氢乳清酸脱氢酶抑制剂F01WB-1315A，B | |
| 引用本文： | 齐巧娟,路新华,郑智慧,李业英,范玉玲,朱京童,任晓,崔晓兰,石英,李韶菁,张华,赵宝华.微生物来源的二氢乳清酸脱氢酶抑制剂F01WB-1315A，B[J].微生物学报,2009,49(4):485-491. |
| 作者姓名： | 齐巧娟 路新华 郑智慧 李业英 范玉玲 朱京童 任晓 崔晓兰 石英 李韶菁 张华 赵宝华 |
| 作者单位： | 1. 河北师范大学生命科学学院,石家庄,050016 2. 华北制药集团新药研发中心,石家庄,050015 3. 中国医学科学院药物研有所,北京,100094 |
| 基金项目： | 国家科技部药用微生物菌种资源标准化整理、整合及共享试点项目（2005DKA21203） |
| 摘 要： | 摘要：目的 从微生物次生代谢产物中筛选免疫相关疾病治疗药物重要靶点—－二氢乳清酸脱氢酶的抑制剂。方法 利用自建的快速、高效的二氢乳清酸脱氢酶抑制剂的高通量筛选方法，从4560株真菌菌株中筛选阳性菌株。阳性菌株的发酵产物进行分离纯化获得活性化合物，再通过对活性化合物的紫外、质谱、核磁等理化数据的分析进行结构鉴定。结果 筛选分离得到2个活性化合物F01WB-1315A和F01WB-1315B。F01WB-1315A对二氢乳清酸脱氢酶有强的抑制活性，IC50=0.07 μg/mL，于20 μg/mL浓度下对体外 |
| 关 键 词： | 关键词: 二氢乳清酸脱氢酶 免疫抑制剂 壳二孢呋喃酮 壳二孢氯素 来氟米特 |
| 收稿时间： | 2008/10/14 0:00:00 |
| 修稿时间： | 2008/12/10 0:00:00 |
F01WB-1315 A and B, two dihydroorotate dehydrogenase inhibitors from microbial metabolites |
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| Qiaojuan Qi,Xinhua Lu,Zhihui Zheng,Yeying Li,Yuling Fan,Jingtong Zhu,Xiao Ren,Xiaolan Cui,Ying Shi,Shaojing Li,Hua Zhang and Baohua Zhao.F01WB-1315 A and B, two dihydroorotate dehydrogenase inhibitors from microbial metabolites[J].Acta Microbiologica Sinica,2009,49(4):485-491. | |
| Authors: | Qiaojuan Qi Xinhua Lu Zhihui Zheng Yeying Li Yuling Fan Jingtong Zhu Xiao Ren Xiaolan Cui Ying Shi Shaojing Li Hua Zhang and Baohua Zhao |
| Institution: | College of Life Science, Hebei Normal University, Shijiazhuang 050016, China;National Microbial Medicine Engineering & Research Center, New Drug R&D Co. Ltd of North China Pharmaceutical Group Co. Ltd, Shijiazhuang 050015, China;National Microbial Medicine Engineering & Research Center, New Drug R&D Co. Ltd of North China Pharmaceutical Group Co. Ltd, Shijiazhuang 050015, China;National Microbial Medicine Engineering & Research Center, New Drug R&D Co. Ltd of North China Pharmaceutical Group Co. Ltd, Shijiazhuang 050015, China;National Microbial Medicine Engineering & Research Center, New Drug R&D Co. Ltd of North China Pharmaceutical Group Co. Ltd, Shijiazhuang 050015, China;National Microbial Medicine Engineering & Research Center, New Drug R&D Co. Ltd of North China Pharmaceutical Group Co. Ltd, Shijiazhuang 050015, China;National Microbial Medicine Engineering & Research Center, New Drug R&D Co. Ltd of North China Pharmaceutical Group Co. Ltd, Shijiazhuang 050015, China;National Microbial Medicine Engineering & Research Center, New Drug R&D Co. Ltd of North China Pharmaceutical Group Co. Ltd, Shijiazhuang 050015, China;National Microbial Medicine Engineering & Research Center, New Drug R&D Co. Ltd of North China Pharmaceutical Group Co. Ltd, Shijiazhuang 050015, China;Institute of Materia Medica Chinese Academy of Medical Science & Peking Vnion Medical College, Beijing 100094 , China;National Microbial Medicine Engineering & Research Center, New Drug R&D Co. Ltd of North China Pharmaceutical Group Co. Ltd, Shijiazhuang 050015, China;College of Life Science, Hebei Normal University, Shijiazhuang 050016, China |
| Abstract: | |
| Keywords: | Keywords: Dihydroorotate dehydrogenase Immunosuppressant Ascofuranone Ascochlorin leflunomide |
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