四年间酵母样真菌感染的病原菌分布与耐药特征分析

目的了解临床酵母样真菌感染的流行特点及其耐药性,指导临床合理运用抗真菌药物。方法运用WHONET软件对中南大学湘雅三医院4年间临床分离出的酵母样真菌与其耐药进行回顾性分析。结果4年间临床酵母样真菌感染率由2002年的9.0%升至2005年的13.8%,白色念珠菌仍是引起临床感染的主要真菌,但其构成比由2002年的69.7%降至2005年的49.1%,而近平滑念珠菌的构成比4年间增加了9.5%,成为临床酵母样真菌感染的第二位病原菌。4年间临床酵母样真菌对唑类药物的耐药率增加了9.6%~16.8%。结论临床酵母样真菌引起的感染逐年增加,种类增多,对唑类药物的耐药情况日趋严重,应加强对临床真菌感染与耐药性情况的监测,以指导临床合理使用抗生素。

Analysis of drug-resistant patterns and pathogenic fungus distribution of yeast-like fungus in the past four years

Objective To analysis the epidemic character and drug resistance of yeast-like fungus, and to guide reasonable using of antifungal agents in clinic. Methods WHONET software was used to retrospectively analyze the yeastlike fungus and their drug-resistance which were isolated from the samples of our hospital during the past four years. Results The infection rate of yeastlike fungus increased from 9.0% in 2002 to 13.8% in 2005. C. albicans remained the main pathological fungus in clinic, but its constituent ratio decreased from 69.7% in 2002 to 49.1% in 2005 ,while the constituent ratio of C. parapsilosis increased by 9.5% during the past four years, and became the second important pathogenic yeast-like fungus infection in clinic. The drug-resistant rate of yeast-like fungus to azoles increased by 9.6% - 16.8% during the past four years. Conclusions Infection caused by yeast-like fungus increased year by year, and the drug-resistance to azoles was increasingly serious . We should pay more attention to the monitor of clinical fungus infection and its drug-resistance in order to guide the reasonable use of antibiotics in clinic.