金黄色葡萄球菌对碘伏、乙醇、高铁酸钾和紫外线的抗性

目的了解临床分离的耐甲氧西林金黄色葡萄球菌（methicillin resistant Staphylococcus aureus,MR-SA）、甲氧西林敏感的金黄色葡萄球菌（methicillin sensitive Staphylococcus aureus,MSSA）及金黄色葡萄球菌CMCC（B）26003对碘伏、乙醇医院常用消毒剂及紫外线的抗性。方法以临床连续收集的67株金黄色葡萄球菌为实验菌株。测定碘伏、乙醇、高铁酸钾对耐甲氧西林金黄色葡萄球菌（MRSA）、甲氧西林敏感的金黄色葡萄球菌（MSSA）和金黄色葡萄球菌CMCC（B）26003作用1、2min后的最小抑菌浓度（MBC）及紫外线作用不同时间后的杀菌试验,观察其对碘伏、乙醇、高铁酸钾及紫外线抗性的变化趋势。结果碘伏对MRSA的MBC明显高于MSSA及CMCC（B）26003,而乙醇、高铁酸钾对3种菌的最小抑菌浓度均相近,3种菌对紫外线抗性相近。结论在正常使用浓度范围内碘伏、乙醇、高铁酸钾对金黄色葡萄菌中无论是MRSA、MSSA都有很好的灭菌作用,且乙醇作用时间越长,抑菌效果越显著。紫外线在作用75min以上时,3种菌全部不能存活。

The resistant of Staphylococcus aureus to iodophor, alcohol, potassium ferrate and UV

Objective To understand the resistance of clinically isolated MRSA,MSSA and CMCC （B） 26003 to iodophor,ethanol,two disinfectants commonly used in hospital and UV. Methods 67 strains of Staphylococcus aureus continuously collected were used as the experimental strains. Iodophor,ethanol,potassium ferrate as weel as UV were used to treat the experimental strains for certain times,then the MBCs were determined and the changes of the resistances were observed.Results Iodophor showed an obviously higher MBC to MRSA than to MSSA and CMCC（B）26003,while the MBCs of ethanol and potassium ferrate to the 3 types of strain were similar. The resistances of the 3 types to UV were also similar.Conclusion Within commonly used concentration range,iodophor,ethanol and potassium ferrate all have satisfactory sterilizing effect on both MRSA and MSSA. No strains could survive when treated with UV for more than 75 minutes.