临床病原菌种类及耐药性监测

目的 探讨病原菌种类及其对抗菌药物的耐的耐药状况。方法 收集１９９８年１月－１９９９年１２月临床感染标本分离的病原菌并分析其种类，药敏试验采用Ｋｉｒｂｙ－Ｂａｕｅｒ纸片扩散法。结果 １１８２株病原菌，革兰氏阳性球菌６０４株（５１．１％），革兰氏阴性杆菌５７８株（４８．９％）。病原菌以金黄一萄球菌、大肠埃希菌、表皮葡萄球菌、铜绿假单胞菌最多见。去甲万古霉素、阿米卡星、新霉素对革兰氏阳性球菌抗菌作用较

THE MONITORING OF KINDS AND BACTERIAL RESISTANCE OF CLINICAL ISOLATES

Objective To investigate the kinds of clinical isolates and their drug resistance to antimicrobial agents.Methods We collected the isolates from infectious samples in 1998 and 1999 and analysed the bacteria kinds.Bacterial susceptivity test was carried out by using Kirby Bauer method.Results Total of 1182 clinical isolates,including 604 strains (51.1%)of Gram positive cocci and 578 strains (48.9%) of Gram nagative bacilli were tested against 18 antimicrobial agents.S.aureus,E.Coli,S.epidermidis and P.aesuginosa were main microorganisms. Norvancomycin,amikacin and neomycin were the most active agents against Gram positive cocci.PolymyxinB,cetazidime and amikacin were the most active agents against Gram negative organisms.The others were drug fast against clinical isolates in different degrees. Conclusion The kinds of clinical bacteria is changing,their drug resistance to antimicrobial agents is serious.It is suggested that there is urgent need for surveillance of bacterial resistance and rational use of antimicrobial agents should be emphasised during clinical therapy.