2008-2010年嗜麦芽窄食单胞菌医院感染的临床分布及耐药性分析

目的了解医院感染嗜麦芽窄食单胞菌（Stenotrophomonasmaltophilia，Sm）的临床分布及耐药性情况，为临床诊治提供依据。方法采用回顾性资料，对中山大学附属第三医院2008—2010年间住院患者的各种临床标本中分离到的Sm及其药敏结果进行统计分析。结果Sm主要来源于呼吸道标本（痰及咽拭子），占82．97％，临床分布以肝胆外科最多，占25．27％，其次为感染科（21．43％），ICU和神经外科均占8．79％；40岁以上的中老年患者占75．82％；Sm对复方新诺明的敏感率最高，达84．40％，其次为左氧氟沙星（81．21％），对头孢他啶和替卡西kS／克拉维酸的敏感性均较低（〈40％）。结论该院感染Sm的易感人群主要是以中老年患者为主，Sm对CLSI推荐的抗菌药物已有一定的耐药性，临床应高度重视，控制感染。

Clinical distribution and antibiotic resistance of Stenotrophomonas maltophilia from 2008 to 2010

Objective To investigate the clinical distribution and drug resistance of Stenotrophomonas maltophilia （Sin） and provide theoretical basis for treatment. Methods The distribution and drug resistance of Sm strains iso- lated in our hospital from 2008 to 2010 were retrospectively analyzed. Results Most of the Sm strains came from sputum specimens and throat swabs （82.97%）, which distributed mainly in Hepatobiliary Surgery （25.27%）, Infectious Diseases Department （21.43%） , ICU （8.79%） and Neurosurgery （8.79%）. 75.82% of the strains were isolated from middle-aged and elderly patients. The highest susceptibility rate of the isolates was to eotrimox- azole （84.40%）, followed by levofloxacin （81.21%） ; the susceptibility rates to ceftazidime and Ticarcillin/cla- vulanic acid were lower （ 〈 40% ）. Conclusion Most of the Sm strains were isolated from middle-aged and elder- ly patients in our hospital, which were resistant to many kinds of antibiotics including CLSI recommended drugs.