| 广东食管癌中Epstein-Barr病毒感染与细胞增殖p53的关系 |
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| 引用本文： | 陶仪声,宗永生.广东食管癌中Epstein-Barr病毒感染与细胞增殖p53的关系[J].中国微生态学杂志,2002,14(2):98-99. |
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| 作者姓名： | 陶仪声 宗永生 |
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| 作者单位： | 1. 蚌埠医学院,病理教研室,安徽,蚌埠,233003
2. 中山医科大学,病理教研室,广东,广州,510089 |
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| 基金项目： | 美国中华医学基金会资助 |
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| 摘 要： | 目的 :研究食管癌中 EB病毒感染情况 ,探讨其与肿瘤细胞增殖及抑癌基因 p5 3的关系。方法 :应用聚合酶链反应技术 (PCR)检测食管癌中 EB病毒 DNA的感染。用免疫组化方法检测其中 p5 3的表达及肿瘤细胞增殖。结果 :2 4例食管癌中 ,EB病毒 DNA阳性率为 95 .8% (2 3/2 4)。 2 3例阳性病例中存在 p5 3蛋白积聚者为 16例 ,积聚率为 6 9.6 % (16 /2 3) ;1例 EB病毒 DNA阴性者 ,p5 3蛋白染色阴性。 p5 3蛋白积聚与增殖细胞核抗原的表达密切相关 (P<0 .0 5 )。结论 :广东食管癌中普遍存在 EB病毒的感染。有 EB病毒感染的病例 ,亦存在 p5 3蛋白积聚。 EB病毒可能与 p5 3的改变有关 ,从而导致细胞增殖。
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| 关 键 词： | 广东 食管癌 Epstein－Barr病毒感染 细胞增殖 p53 EB病毒 |
| 文章编号： | 1005-376X(2002)02-0098-02 |
| 修稿时间： | 2001年10月25 |
EPSTEIN-BARR VIRUS INFECTION IN ESOPHAGEAL CARCINOMA OF GUANGDONG IN RELATION TO CELL PROLIFERATION AND P53 |
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| TAO Yi-sheng,ZONG Yong-sheng.EPSTEIN-BARR VIRUS INFECTION IN ESOPHAGEAL CARCINOMA OF GUANGDONG IN RELATION TO CELL PROLIFERATION AND P53[J].Chinese Journal of Microecology,2002,14(2):98-99. |
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| Authors: | TAO Yi-sheng ZONG Yong-sheng |
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| Abstract: | Objective:To study the infection of Epstein-Barr virus in esophageal carcinoma of Guangdong and its relationship with cell proliferation and p53.Methods:24 cases of esophageal carcinoma were detected by PCR with EBV and by using immunohistochemical technic for p53 and PCNA.Results:By PCR,EBV DNA was detected in 23 cases(95.8%,23/24).In the EBV-positive cases( n =23),p53 protein positive rates was 69.6%(16/23);In the EBV-negative cases ( n =1),p53 protein was not detected.P53 protein accumulation was close correlated with PCNA ( P <0.05).Conclusions:There are EB virus infection in esophageal carcinoma of Guangdong.In the EBV-positive cases,p53 protein accumulate also.EBV infection is correlated with p53 and cell proliferation in esophageal carcinoma of Guangdong. |
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| Keywords: | Esophageal carcinoma EB virus p53 PCNA PCR |
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