铜绿假单胞菌对11种抗生素的耐药性差异

目的探讨不同标本分离铜绿假单胞菌对11种抗生素耐药性的差异,指导临床合理使用抗生素。方法按常规方法培养分离后,经VITEK-AMS60或VITEK-II自动微生物鉴定分析仪的鉴定,用Kirty-Bauer法做药物敏感试验。结果尿液与血液之间,以及尿液与伤口分泌物之间,分离株均对所检测的11种抗生素的耐药性差异有非常显著性（P〈0.01）,尿液与穿刺液分离菌对除亚胺培南和美洛培南外的9种抗生素的耐药性差异有非常显著性（P〈0.01）,血液与穿刺液、血液与伤口分泌物和穿刺液与伤口分泌物间,除穿刺液与伤口分泌物分离菌对美洛培南的耐药性差异有显著性（P〈0.05）外,其他差异均无显著性（P〉0.05）。结论不同标本来源铜绿假单胞菌对哌拉西林等11种抗生素存在耐药性差异。

The Resistance difference of Pseudomonas aeiuginosa to 11 antibiotics

Objective To investigate the difference between Pseudomonas aeiuginosa strains from different types of sample with regard to their resistence to 11 antibiotics.Method After being cultrured ,the strains were identified by VITEK-AMS60 or VITEK-II Microbe ldentification System. The antibiotic susceptibility of the strains was detected by Kirty -Bauer method. Result The antibiotic resistances of the strains showed significant difference between the strains from urine and those from blood,so did the resistances between the strains from urine and those from puncture fluid （P〈0.01）.There was difference between the antibiotic resistance of the strains from urine and that of the strains from wound secretion.Conclusion Pseudomonas aeruginosa from different types of samples shows different antibiotic resistances to these 11 antibiotics.