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灵芝发酵液多糖提取物对荷瘤小鼠细胞免疫的动态观察
引用本文:曹婧,徐玉珍,宁安红,李楠,周丽娜,吴春艳,吴贵忠,颜杨杨,黄敏.灵芝发酵液多糖提取物对荷瘤小鼠细胞免疫的动态观察[J].中国微生态学杂志,2004,16(3):140-141,143.
作者姓名:曹婧  徐玉珍  宁安红  李楠  周丽娜  吴春艳  吴贵忠  颜杨杨  黄敏
作者单位:1. 大连医科大学基础医学院,微生物学教研室,辽宁,大连,116027
2. 大连医科大学附属二院
3. 大连医科大学,医疗系
摘    要:目的:观察灵芝发酵液多糖提取物对S180荷瘤小鼠部分免疫指标的动态调节作用,探讨其抗肿瘤机制.方法:S180瘤细胞荷瘤昆明小鼠80只建立动物模型,生理盐水组(NS组)与灵芝发酵液多糖组(GFG组)各40只,分别于荷瘤后第4,7,10,13,16天每组各处死8只小鼠,检测GFG对NK细胞活性、淋巴细胞转化率的影响.结果:GFG能显著提高荷瘤小鼠NK细胞活性和淋巴细胞转化率.随荷瘤时间延长,GFG组较NS组能维持较高水平(P<0.01),但总体呈下降趋势.结论:灵芝发酵液多糖提取物能显著提高NK细胞活性和淋巴细胞转化率,并维持一定水平.

关 键 词:灵芝发酵液多糖提取物  小鼠  免疫  动态
文章编号:1005-376X(2004)03-0140-03

Dynamic regulating effects of Ganoderma lucidum fermentative polysaccharides on the immune system of the mice with S180 tumor
CAO Jing,XU Yu-zhen,NING An-hong,et al..Dynamic regulating effects of Ganoderma lucidum fermentative polysaccharides on the immune system of the mice with S180 tumor[J].Chinese Journal of Microecology,2004,16(3):140-141,143.
Authors:CAO Jing  XU Yu-zhen  NING An-hong  
Institution:CAO Jing,XU Yu-zhen,NING An-hong,et al .
Abstract:Objective: To observe the dynamic regulating effects of GFG on the immune system of the mice with S180 tumor bearing and discuss its mechanism.Methods:80 Kungming mice were borne with S180 to build animal model.Then,they were divided into 10 groups randomly,5 groups were NS control groups,the other 5 groups were GFG-treated groups.One group of NS control groups and GFG-treated groups were killed respectively at the 4th,7th,10th,13th,16th day after bearing tumor.Study the dynamic effects of GFG on NK activity and Lymphocytes(LM) transforming rates.Results:GFG could obviously improve the NK activity and LM transforming rates of tumor-bearing mice( P <0.01),With time passing by,NK activity and LM transforming rates of GFG-treated groups maintain higher than NS groups ( P <0.01) but both gradually decreased.Conclusion:GFG could significantly improve the NK cell activity and Lymphocytes transforming rates of tumor-bearing mice.
Keywords:GFG  Murine  Immunity  Dynamic
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