短链脂肪酸在宿主能量代谢方面的调节作用

肠道菌群数量庞大,对宿主多种生理活动具有重要调节作用。现有研究发现,肠道菌群主要通过调节其产生的不同代谢产物,参与宿主物质代谢反应,改变能量代谢水平,影响机体炎症反应。在诸多代谢产物中,短链脂肪酸(醋酸盐、丙酸盐、丁酸盐等)具有重要调节作用,对机体代谢功能方面具有深远影响。本文结合国内外相关研究文献,综述了短链脂肪酸在调节机体能量代谢方面的相关研究,以期为进一步阐明其在机体能量代谢方面的作用提供科学依据。

The regulation of short chain fatty on host energy metabolism

Abstract: The large number of gut microbiota (GM) plays an essential role in various physiological activities. Existing studies have found that GM participates in the metabolic reactions, changes the metabolic level and affects the systemic inflammatory responses mainly through regulating the products of different metabolisms. Among those products, short chain fatty acids (SCFAs), which include acetate, propionate and butyrate, etc., are vital for body metabolism and immune system. SCFAs have a wide range of functions in metabolism, immune responses and other physiological activities. Combined with previous studies, this review makes an overview of functions of SCFAs on body metabolism and immune system, in order to sum up the effects of SCFAs on body metabolism.