益生菌在儿童炎症性肠病中的应用

炎症性肠病(inflammatory bowel disease,IBD)是一种原因不明的慢性非特异性肠道炎性疾病,主要包括溃疡性结肠炎(ulcerative colitis,UC)、克罗恩病(Crohn′s disease,CD)和未定型的炎症性肠病(IBD-unclassified,IBDU)。随着对肠道微生物与IBD关系认识的不断加深,许多研究发现肠道菌群的生态失调在IBD的发病中起着重要作用。益生菌在儿童IBD治疗中具有良好前景,但仍缺乏有效的证据来确证益生菌疗效,并指导临床对益生菌的种类和剂量等进行选择。现有研究表明,益生菌对儿童IBD的治疗具有特异性,在诱导和维持UC缓解效果明显,但在诱导CD缓解、维持CD缓解和预防术后并发症及复发方面效果并不理想。

Application of probiotics in children with inflammatory bowel disease

Abstract: Inflammatory bowel disease (IBD) is an unexplained chronic nonspecific intestinal inflammatory disease, including ulcerative colitis (UC), Crohn''s disease (CD) and IBD unclassified (IBDU). With more knowledge about the relationship between gut microbes and IBD has been learned, many studies have found that the ecological imbalance of gut flora plays an important role in the pathogenesis of IBD. Probiotics showed good prospects in the treatment of IBD in children. But there is still lack of effective evidences to confirm the efficacy of probiotics and guide the clinical selection of dosages and categories. The existing researches showed that probiotics are specific to the treatment of pediatric IBD and have obvious effect in inducing and maintaining the remission of UC, however, they are not effective in inducing and maintaining the remission of CD and in preventing postoperative complications and recurrences.