| 整合子与多重耐药大肠埃希菌相关性研究 |
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| 引用本文： | 李彬,傅蔷,黄心宏,曹颖平,潘玉红.整合子与多重耐药大肠埃希菌相关性研究[J].中国微生态学杂志,2010,22(2):135-137,141. |
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| 作者姓名： | 李彬 傅蔷 黄心宏 曹颖平 潘玉红 |
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| 作者单位： | 福建医科大学附属协和医院,检验科,福建,福州,350001 |
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| 基金项目： | 福建省卫生厅青年科研基金 |
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| 摘 要： | 目的探讨整合子在多重耐药大肠埃希菌耐药性中的作用。方法对临床分离的93株多重耐药大肠埃希菌的I、Ⅱ型整合酶基因进行检测,并分析药敏结果。结果多重耐药临床分离株中Ⅰ型整合子阳性率为60.2%。所检出整合子共有3种长度即1000、1600和2000 bp;主要携带aadA和dfrA类基因盒;未检出Ⅱ型整合子。结论整合子形成是细菌产生多重耐药的重要原因。
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| 关 键 词： | 多重耐药 大肠埃希菌 整合子 |
Study on structure of integron in multi-drug resistant E.coli |
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| LI Bin,FU Qiang,HUANG Xin-hong,CAO Ying-ping,PAN Yu-hong.Study on structure of integron in multi-drug resistant E.coli[J].Chinese Journal of Microecology,2010,22(2):135-137,141. |
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| Authors: | LI Bin FU Qiang HUANG Xin-hong CAO Ying-ping PAN Yu-hong |
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| Institution: | LI Bin,FU Qiang,HUANG Xin-hong,CAO Ying-ping,PAN Yu-hong(Department of Clinical Laboratories,the Affiliated Union Hospital of Fujian Medical University,Fuzhou 350001,China) |
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| Abstract: | Objective To study the relationship between integrons and multi-drug resistance in E. coli. Method Class Ⅰ and Ⅱ integrons were detected by PCR; Various regions of Class Ⅰ integron were sequenced. Result Class Ⅰ inte-grons were screened from 93 isolates with the positive rate of 60.2%. Three types of integrons were detected with their lengths being 1000 bp, 1600 bp and 2000 bp respectively. Most of these genes carried aadA and dfrA gene cassatte. Class Ⅱ integrons were not detected. Conclusion Integrons are important molecular mechanism in the devdopment of multidrug resistance of E. coll. |
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| Keywords: | Multidrug resistance Escherichia coli Integron |
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