2009年中国流行的甲型流感病毒（H1N1）血凝素特征分析

目的研究甲型流感病毒（H1N1）暴发流行以来中国各地甲型流感病毒血凝素（HA）的特征。方法搜索甲型流感病毒（H1N1）暴发流行以来中国各地报道的血凝素（HA）的氨基酸序列,比较当年不同时期血凝素（HA）的氨基酸序列的变化,并比较2009年报道的血凝素（HA）的氨基酸序列和2008年、2007年报道的血凝素（HA）的氨基酸序列作比较,以分析和前2年血凝素（HA）氨基酸序列相比所发生的变化。结果2009年中国各地甲型流感病毒（H1N1）的血凝素（HA）的氨基酸序列（人源）的同源性为99%-100%,但和2008年以及2007年的同源性非常低,分别为70%-77%和71%-90%。结论2009年暴发流行的甲型流感病毒（H1N1）的血凝素氨基酸序列较往年发生了很大程度的变异,这可能是今年甲型流感病毒（H1N1）暴发流行的主要原因。

The study of character of Influenza A (H1N1) virus hemagglutinin in 2009 in china

Objective To study the character of influenza A（H1N1） virus hemagglutinin in china after influenza A（H1N1） virus prevalence.Method The influenza A（H1N1） virus hemagglutinin amino acid sequences in china after the prevalence was searched,and these sequences were compared each other,and with influenza A（H1N1） virus hemagglutinin amino acid sequences in 2007 and 2008 in china in order to find out variety of hemagglutinin amino acid sequences of influenza A（H1N1） virus.Result Homology of hemagglutinin amino acid sequences come from people in 2009 in china was 99% - 100%, and their Homology were respectively 70% - 77% and 71% - 90% that these sequences in 2009 were compared with hemagglutinin amino acid sequences in 2007and 2008. Conclusion Hemagglutinin amino acid sequences in china in 2009 have great variety compare with sequences in 2007 and 2008, which may be main causes of influenza A（H1N1） virus prevalence in 2009 in china.