| 0710合生元结肠靶向微生态调节剂体外释放及定位作用研究 |
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| 引用本文： | 于莲,杨景云,孙维彤,苏瑾.0710合生元结肠靶向微生态调节剂体外释放及定位作用研究[J].中国微生态学杂志,2010,22(1):29-31,35. |
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| 作者姓名： | 于莲 杨景云 孙维彤 苏瑾 |
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| 作者单位： | 1. 佳木斯大学药学院,黑龙江省高校重点实验室,黑龙江,佳木斯,154007
2. 佳木斯大学基础医学院,医学系,黑龙江,佳木斯,154007 |
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| 摘 要： | 目的将益生菌双歧杆菌与枸杞多糖提取物设计为口服结肠定位给药系统(OCDDS),制备0710合生元结肠靶向微生态调节剂,考查其体外释放行为及体内定位作用。方法以枸杞中多糖为指标,对制剂进行体外溶出实验,并利用X-射线跟踪技术验证0710合生元结肠靶向微生态调节剂在人体内的靶向性。结果该制剂在人工胃液2 h、人工小肠液4 h,几乎不释药,而在人工结肠液中6 h释药达到100%,符合中国药典2005年版对缓释制剂的规定,且体内实验在结肠中黏附性较好。结论0710合生元结肠靶向微生态调节剂在体外结肠液中释放良好,在体内结肠具有靶向性,达到制剂设计要求。
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| 关 键 词： | 微生态调节剂 口服结肠定位系统 体外释放 体内定位 |
In vitro release and localization study of 0710 synbiotics colonic targeting microecological modulator |
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| YU Lian,YANG Jing-yun,SUN Wei-tong,SU Jin.In vitro release and localization study of 0710 synbiotics colonic targeting microecological modulator[J].Chinese Journal of Microecology,2010,22(1):29-31,35. |
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| Authors: | YU Lian YANG Jing-yun SUN Wei-tong SU Jin |
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| Institution: | YU Lian1,YANG Jing-yun2,SUN Wei-tong1,SU Jin1(1.Pharmacy College of Jiamusi University,Key Laboratory in Colleges of Heilongjiang,Jiamusi 154007,China,2.Basic Medical College of Jiamusi University,China) |
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| Abstract: | Objective To design the oral colonic drug delivery system(OCDDS) and prepare 0710 colonic targeting synbiotics microecological modulator,combining bifidobacterium and medlar amylose,and in vitro release characteristics and colonic-targeting behavior in vivo was investigated.Method Dissolution testing was studied taking amylose as the index,and the X-Ray tracing technique was applied to inspect the colonic-targeting behavior of 0710 OCDDS in vivo.Result The amylose was not released in simulated gastric juice... |
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| Keywords: | Microecological modulator Oral colonic drug delivery system In vitro release Localization |
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