| sICAM-1在多发性硬化症发病机制中的作用探讨 |
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| 引用本文： | 吴晓秋,张凤蕴,徐雯,杨景云,唐建民,王丽群,李殿俊.sICAM-1在多发性硬化症发病机制中的作用探讨[J].中国微生态学杂志,2002,14(5):264-265. |
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| 作者姓名： | 吴晓秋 张凤蕴 徐雯 杨景云 唐建民 王丽群 李殿俊 |
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| 作者单位： | 1. 佳木斯大学,黑龙江,佳木斯,154007
2. 哈尔滨医科大学,免疫教研室,黑龙江,哈尔滨,150086 |
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| 基金项目： | 黑龙江省自然科学基金资助项目 ( 2 0 0 2 - ) |
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| 摘 要： | 目的：探讨可溶性粘附分子－1（sICAM-1）在多发性硬化症发病机制中的作用。方法：用ELISA（双抗体夹心法）检测15例未经治疗的多发性硬化症患者血清中sICAM-1的水平，以15例正常人作对照。结果：患者血清中sICAM-1水平显著高于正常对照组（P＜0．01）；复发期患者sICAM-1水平显著高于缓解期。结论：sICAM-1可能是中枢神经系统急性炎症的标志之一；血清中sICAM-1水平的测定对临床诊断，预测复发具有一定意义。
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| 关 键 词： | sICAM－1 多发性硬化症 发病机制 作用 可溶性细胞粘附分子－1 |
| 文章编号： | 1005-376X(2002)05-0264-03 |
| 修稿时间： | 2002年8月1日 |
SICAM-1 ASSAY IN PATIENTS WITH MULTIPLE SCLEROSIS AND INVESTINGATE THE ADHESION MOLECULES OF MULTIPLE SCLERAOSIS |
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| WU Xiao qiu,ZHANG Feng yun,XU Wen,et al.SICAM-1 ASSAY IN PATIENTS WITH MULTIPLE SCLEROSIS AND INVESTINGATE THE ADHESION MOLECULES OF MULTIPLE SCLERAOSIS[J].Chinese Journal of Microecology,2002,14(5):264-265. |
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| Authors: | WU Xiao qiu ZHANG Feng yun XU Wen |
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| Abstract: | Objective:To investingate the change and effect of adhesion molecules in the immuneopathogenisis of multingate scleraosis(MS) Methods:Soluble intercellular adhesion molecule 1(sICAM 1)level of serum in 15 MS patients and 15 subjects in healthy control were examined by ELISA.Results:The sICAM 1 level in MS patients group were obviously higher than that of control group( P <0 01),furthermore the sICAM 1 level of serum in relapsing patients was obviously higher than that of remitting patients( P <0 01) Conclusions:sICAM 1 may serve as a marker of acute inflammatory events in the brain;examination of sICAM 1 in serum of MS patient may be useful in diagnosis,judgement of disease phage,and prediction of relapse. |
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| Keywords: | Multiple sclerosis Adhesion molecule Soluble intercelluar adhesion molecule 1 |
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