108例鼠伤寒沙门氏菌医院内感染临床分析

1988年8月至1991年6月在我院婴儿室及儿科病房发生和收治鼠伤寒沙门氏菌病153例,其中108例占64.1％为医院内感染。发病率龄以12个月以内婴幼儿为主占85.6％。连续两年于8月份在婴儿室呈爆发流行共48例占44.4％。本病全年均可发病,以8～10月为发病高峰。医院内感染的主要传染源为院外感染的散发病例收住院的患者及陪住家属的带菌者。消毒隔离制度不严格是引起传播的重要因素。该病原菌耐药性强,尤其院内感染菌株。院内感染延长住院时间,增加病人痛苦及经济负担,因此医院内感染必须引起重视,急待控制。

THE OUTBREAKS OF NOSOCOMIAL INFECTION CAUSED BY S. TYPHIMURIUM A CLINICAL ANALYSIS OF 108 CASES

108 infants or children who suffered nosocomial infection caused by S. typhimurium from August 1988 to June 1991 were reported in this paper. 85.6% of 108 cases were infants under 1 year. 48 cases of S. typhimurium were found in hospital infant room and 60 cases in paediatric ward where the patients were recieving therapy for other disease. Cultures of specimens from patient's stool and the surrounding environment were positive for S. typhimurium. Antibacteriai activity of 15 antibiotic on the positive strains was assayed. The result showed that only amikacin were sensitive against S. typhimurium. The authors suggested that S. typhimurium be one of main pathogen for nosocomial infection and multiple measures (including the patient's isolation, controll of sourses of infection, cutting the contagious way and protecting the susceptible populations) should be taken to decrease the nosocomial infection.