大肠埃希菌耐药与抗菌药物使用量的相关性研究

目的探讨大肠埃希菌的耐药率与多种抗菌药物使用量之间的相关关系。方法计算主要抗菌药物每百床日的用药频度（DDDs），以及温州医学院附属第一医院院内感染大肠埃希菌的耐药率，并采用多元线性回归的方法进行分析。结果大肠埃希菌对头孢他啶的耐药率与头孢哌酮和头孢克罗的用量呈负相关，与头孢他啶的用量呈正相关；对庆大霉素的耐药率与头孢他啶、哌拉西林的用量里负相关；对亚胺培南的耐药率与哌拉西林用量呈正相关，与季度呈负相关；对复方新诺明的耐药率与阿米卡星用量呈正相关；对呋喃妥因的耐药率与头孢他啶、去甲万古霉素用量呈负相关。结论在大肠埃希菌耐药水平和抗菌药物使用量之间存在相关关系。

The relationship between antimicrobial consumption and rates of resistance of Escherichia coli

Objective To investigate the relationship between antimicrobial consumption and rates of resistance of Escherichia coli. Methods By calculating the defined daily doses(DDDs) /100 patient days of antimicrobial drugs and rates of resistance of Escherichia coli that caused hospital infection.The data were analyzed using multiple linear regression analysis. Results The rate of resistance of Escherichia coli to ceftazidime was significantly negatively associated with the usage of cefoperazone and cefaclor,and positively associated with the usage of ceftazidime.A significant negative association was observed between the rate of resistance to gentamycin and the usage of ceftazidime and piperacillin.The rate of resistance to imipenem had a significant positive association with the usage of piperacillin,and a negative association with season.There was a significant positive association between the rate of resistance to compound sulfamethoxazde and the usage of amikacin,and a negative association between the rate of resistance to nitrofurantoin and the usage of ceftazidime and norvancomycin.Conclusion A relationship existed between antimicrobial consumption and rates of resistance of Escherichia coli.