整合子-基因盒系统与细菌耐药机制的研究进展

大量研究表明整合子-基因盒系统是微生物耐药的主要机制，由其介导的耐药基因水平转移是细菌耐药机制产生的主要途径。已知的整合子被分为两大类：传统的整合子和超级整合子。前者存在于转座子、质粒和细菌染色体，其基因盒编码产物可使细菌耐受一种或多种抗菌药物及消毒剂；而后者则只存在于细菌的染色体上，它携带的基因盒更多，且其编码产物则更加复杂，目前只在特定菌株中发现超级整合子。本文就整合子的结构、分布、检测及它对细菌耐药性的影响等几个方面的研究进展进行讨论。

The integron-gene cassette system and the mechanism of bacterial drug resistance: research progress

Lots of researches had proved that integrons play a key role in the antibiotic gene transfer among bacteri- a. Integrons are classified into 2 groups ： resistance integrons and super integrons. The resistance integrons are usu- ally detected in transposons, plasmids or chromosomes and able to encode genes which are resistant to single or multiple antibiotics. The super integrons are able to carry as many as hundreds of gene cassettes, which encode genes showing many functions. This article aims at reviewing the structure, occurrence, detection of the integrons and their influence on drug resistance.