| 谷氨酰胺对急进高原大鼠肠道微生态影响的实验研究 |
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| 引用本文： | 张方信,杨文翠,邓芝云,吴文明,吴汉平,陈嘉屿,汪泳,杨玉捷.谷氨酰胺对急进高原大鼠肠道微生态影响的实验研究[J].中国微生态学杂志,2010,22(1):1-4. |
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| 作者姓名： | 张方信 杨文翠 邓芝云 吴文明 吴汉平 陈嘉屿 汪泳 杨玉捷 |
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| 作者单位： | 1. 兰州军区总医院,消化科,甘肃,兰州,730050
2. 兰州军区总医院,检验科,甘肃,兰州,730050 |
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| 摘 要： | 目的探讨谷氨酰胺对急进高原大鼠小肠黏膜形态结构及肠道微生态的影响。方法W istar大鼠50只,随机分为5组:对照组(A组)、3848米未干预组(B组)、3848米谷氨酰胺干预组(C组)、4767米未干预组(D组)和4767米谷氨酰胺干预组(E组),每组10只,急进海拔3848米和4767米造成大鼠急性缺氧模型,检测小肠黏膜上皮细胞形态结构、肠道菌群失衡及细菌易位的变化。结果高海拔缺氧组大鼠小肠黏膜变薄、肠黏膜水肿、绒毛短缩,肠道菌群失衡显著高于对照组(P0.05),且随着海拔升高,菌群失衡更明显。不同海拔高度细菌易位率也有差异。经谷氨酰胺干预后,肠道的菌群失衡及细菌易位率与高海拔缺氧组比较差异有显著性(P0.05)。结论急进高原缺氧环境可导致小肠黏膜损伤、肠道菌群失衡及细菌易位,肠黏膜屏障破坏,且随着海拔升高而上述改变更明显。谷氨酰胺具有保护肠黏膜屏障及调节肠道菌群失衡的作用。
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| 关 键 词： | 谷氨酰胺 急进高原 肠道微生态 细菌易位 |
Effect of glutamine on change of intestinal microecology in rats exposed to acute high altitude |
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| ZHANG Fang-xin,YANG Wen-cui,DENG Zhi-yun,WU Wen-ming,WU Han-ping,CHEN Jia-yu,WANG Yong,YANG Yu-jie.Effect of glutamine on change of intestinal microecology in rats exposed to acute high altitude[J].Chinese Journal of Microecology,2010,22(1):1-4. |
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| Authors: | ZHANG Fang-xin YANG Wen-cui DENG Zhi-yun WU Wen-ming WU Han-ping CHEN Jia-yu WANG Yong YANG Yu-jie |
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| Institution: | ZHANG Fang-xin1,YANG Wen-cui1,DENG Zhi-yun2,WU Wen-ming1,WU Han-ping1,CHEN Jia-yu1,WANG Yong1,YANG Yu-jie1 (1.Department of Gastroenterology,2.Department of Clinical Laboratory,the General Hospital of Lanzhou Military Area Comm,,Lanzhou 730050,China) |
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| Abstract: | Objective To observe the effect of glutamine(GLN) on the morphosis and microecological change of intestinal mucosa in rats exposed to acute high altitude.Method 50 Wistar rats were randomly divided into control(A) group,altitude 3848 meters(B) group,altitude 3848 meters with glutamine intervention(C) group,altitude 4767 meters(D) group and altitude 4767 meters with glutamine intervention(E) group.10 rats in each group.All rats except those in A group were posed acute hypoxia model at radical altitudes of 38... |
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| Keywords: | Glutamine Acute high altitude Intestinal microecology Bacterial translocation |
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