焦米对番泻叶所致腹泻小鼠的止泻及肠道菌群影响研究

目的考察焦米水对肠道菌群失调性腹泻的调节作用。方法将小鼠分为5组,分别为模型组、正常组和生米组、焦米组、自由恢复组三组实验组,除正常组外,用番泻叶水煎液给小鼠灌胃连续6 d造成小鼠腹泻模型,实验组分别给予生米、焦米及生理盐水作为自由恢复组,每天观察各组小鼠腹泻情况,并且于第2天、第6天取小鼠粪便进行肠道菌群检测,并做菌群计数,数据进行统计学处理。结果成功建立了小鼠肠道菌群失调腹泻模型,焦米组小鼠腹泻较生米组和自由恢复组恢复较快,差异有统计学意义（P〈0.05）。给予生米、焦米的小鼠肠道菌群恢复较快,与自由恢复组相比差异有统计学意义（P〈0.05）,焦米组与生米组相比菌群有一定的提高,但差异无统计学意义（P〉0.05）。结论焦米水能明显的改善小鼠的腹泻症状,焦米有一定的提高小鼠肠道菌群,改善小鼠肠道菌群环境的作用。焦米与生米相比对腹泻小鼠的恢复促进调节作用更好,可能跟米炒焦后所生成的新物质有关。

Antidiarrhea effect of coked rice and its influence on intestinal tract bacteria in mice with senna leaf resulted diarrhea

Objective To study coked rice′s regulation effects on the diarrhea resulted from intestinal flora imbalance.Method The mice were divided into model group,normal group,control group,uncooked rice group,coked rice group and natural recovery group.First,all mice except those in normal group were given Folium Sennae decoction to make Diarrhea models,then given rice decoction,coked rice decoction and saline respectively,two times per day.The condition of mice in each group was observed;fecel samples were taken at Days 2 & 6 to detect intestinal flora.Result Mice in Coked rice group recovered more rapidly compared with those in uncooked and natural recovery groups,and the difference was significant(P<0.05).Intestinal flora of coked rice group returned to normal more rapidly than the uncooked rice group,but the difference was not significant.Conclusion Coked rice plays a positive role in diarrhea mice’s recovery;it may be related to certain new components generated in the processing of rice coked rice.