金双歧治疗新生儿高胆红素血症的临床疗效研究

目的 探讨微生态制剂金双歧(双歧杆菌乳酸杆菌三联活菌片)对新生儿高胆红素血症的临床疗效,以找出能及早有效地纠正新生儿高胆红素血症,预防新生儿胆红素脑病发生的新方法.方法 通过随机抽样、收集青白江区人民医院2007年3月至2011年3月72例新生儿高胆红素血症患儿的临床资料并进行回顾性分析,将72例新生儿高胆红素血症患儿随机分为治疗组40例和对照组32例.对照组给予常规治疗,治疗组在常规治疗基础上,加用金双歧1片(0.5亿)/次,每天3次,温开水溶碎后喂服或经胃管注入,共7～10d.检测治疗前后两组血清胆红素水平、计算日平均经皮测胆红素下降值、平均住院时间和黄疸消退时间.结果 金双歧辅助治疗新生儿高胆红素血症,治疗后治疗组与对照组血清总胆红素水平分别为(58.21 +4.36) μmol/L和(64.16±5.29) μmol/L(P ＜0.01)；治疗组和对照组日平均经皮测胆红素下降值、平均住院时间和黄疸退尽平均时间分别为( 10.35±2.46)、(7.68±1.35)μmol/L；( 6/54±2/59)、(9/05 +3/12)d; (6/38±1/38)、( 8/75±2/68)d；差异均有统计学意义(P＜0.01).结论 应用金双歧治疗新生儿高胆红素血症可迅速降低血胆红素水平,缩短治疗时间,预防胆红素脑病的发生疗效确切、安全,可作为治疗新生儿高胆红素血症的方法之一,值得临床应用推广.

Clinical efficacy of Gold Bifid on neonatal hyperbilirubinemia

Objective To investigate the clinical efficacy of Gold Bifid(Live Combined Bifidobacterium and Lactobacillus Tablets) on neonatal hyperbilirubinemia in order to find a new method for identifying early and effectively correct the hyperbilirubinemia as well as preventing neonatal bilirubin encephalopathy.Methods 72 cases of neonatal hyperbilirubinemia in our hospital from March 2007 to March 2011 were collected by random sampling method for retrospective analysis.The 72 cases were randomly divided into two groups,40 in treatment group and 32 in control group.Both the control group and treatment group received conventional therapy,with an extra administration of Gold Bifid,1 tablet(0.5 CFU)/time,3 times a day for 7 to 10 d to the treatment group.The serum bilirubin levels,average daily value of transcutaneous bilirubin,hospitalization period and time to jaundice disappearance before and after treatment were determined.Results The total serum bilirubin levels of the treatment group and control group after treatment were(58.21±4.36) μmol/L and(64.16±5.29) μmol/L(P<0.01) respectively;the average daily value of transcutaneous bilirubin,time to jaundice disappearance,and hospitalization peirod were(10.35±2.46) μmol/L vs(7.68±1.35) μmol/L,(6.54±2.59) d vs(9.05±3.12) d,(6.38±1.38) d vs(8.75±2.68) d,respectively.The differences were all significant(P<0.01).Conclusion Gold Bifid,when used in treatment of neonatal hyperbilirubinemia,can quickly reduce blood bilirubin levels,shorten treatment time,and prevent bilirubin encephalopathy.It is one of the effective and safe methods for the treatment of neonatal hyperbilirubinemia and worth of clinical application and promotion.