| 干法造粒工艺在微生态活菌片剂生产中的应用研究 |
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| 引用本文： | 马征途,刘彦民,龚虹,张丽,张进,冯谦,黄少磊,李林泉.干法造粒工艺在微生态活菌片剂生产中的应用研究[J].中国微生态学杂志,2012,24(6):562-564. |
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| 作者姓名： | 马征途 刘彦民 龚虹 张丽 张进 冯谦 黄少磊 李林泉 |
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| 作者单位： | 内蒙古双奇药业股份有限公司,内蒙古呼和浩特,010010 |
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| 摘 要： | 目的为降低生产成本，保证产品质量，研究干法造粒工艺在微生态活菌片剂生产中的应用。方法测定三批干法造粒和粉末直接压片技术获得的片剂的理化指标和贮藏期间活菌数。结果干法造粒工艺生产的片剂其片重、硬度、崩解时限和干燥失重均符合生产质量要求，且提高了产品的贮藏稳定性。结论干法造粒工艺更适用于微生态活菌片剂生产。
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| 关 键 词： | 干法造粒 粉末直接压片 稳定性 |
Application of dry granulation process in the production of microbial ecological agents |
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| MA Zheng-tu
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LIU Yan-min
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GONG Hong
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ZHANG Li
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ZHANG Jin
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FENG Qian
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HUANG Shao-lei
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LI Lin-quan.Application of dry granulation process in the production of microbial ecological agents[J].Chinese Journal of Microecology,2012,24(6):562-564. |
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| Authors: | MA Zheng-tu LIU Yan-min GONG Hong ZHANG Li ZHANG Jin FENG Qian HUANG Shao-lei LI Lin-quan |
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| Institution: | (Inner Mongolia ShuangQi Pharmaceutical Co,Ltd.,Huhhot 010010,China) |
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| Abstract: | Objective To research the application of dry granulation process in microbial ecological agents production win order to reduce the production cost and ensure product quality.Method The chemical and physical properties and numbers of living bacteria of the agents,three batches each by dry granulation and direct compression,were detected.Result The agents obtained with the dry granulation process showed the following properties: stable tablet weight;increased hardness;disintegration time decreased by 30%;the number of viable cells increased significantly.Conclusion Dry granulation process is more suitable for the production of microecological agents. |
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| Keywords: | Dry granulation Powder pellets Stability |
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