凝结芽孢杆菌活菌片预防小儿肺炎继发性腹泻疗效观察

目的观察和评价凝结芽孢杆菌活菌片（商品名：爽舒宝）与抗菌药联用预防小儿肺炎继发性腹泻的临床疗效。方法将164例肺炎患儿随机分为预防组和对照组，预防组84例，对照组80例，两组均给予抗菌药及对症支持治疗。其中预防组在治疗的同时序贯（间隔2～3h）应用凝结芽孢杆菌活菌片，出现腹泻继续服用；对照组单用抗菌药，出现腹泻用凝结芽孢杆菌活菌片治疗。对两组继发性腹泻的发生率、腹泻持续天数、肺炎治疗的总疗程、腹痛和肠鸣音异常等症状和体征进行统计分析。结果预防组继发腹泻10例，发生率11．9％，对照组继发腹泻41例，发生率51．3％，两组相比差异具有统计学意义（P〈0．01）；预防组腹泻持续时间和治疗疗程显著短于对照组（P〈0．05）；预防组患儿腹痛、肠鸣音异常和脱水等症状和体征发生率均少于对照组（P〈0．05）。结论凝结芽孢杆菌活菌片与抗菌药序贯应用治疗肺炎，能显著降低继发性腹泻的发生率，缩短疗程，值得临床推广。

The curative effects of Bacillus coagulans Tablets in preventing pneumonia-associated diarrhea

Objective To observe and evaluate the efficacy of Bacillus coagulans Tablets combined with antibacterial drug at regular intervals for preventing pneumonia-associated diarrhea.Method 164 infants with pneumonia were randomly divided into two groups,84 infants in prevention group,another 80 infants in control group.Both groups were treated with normal antibacterial therapy.The prevention group was given Bacillus coagulans Tablets two hours after the antibacterial therapy,while the control group was give Bacillus coagulans Tablets when diarrhea occurred.The incidence rate and duration of diarrhea,total course of pneumonia treatment,and untoward effects were observed.Result The incidence of pneumonia-associated diarrhea was 11.9% in prevention group,and 51.3% in control group(P<0.01).The duration of diarrhea and course of treatment in prevention group were significantly shorter than in control group(P<0.01).Symptoms and signs(abdominal pain,abnormal bowel sounds and dehydration etc.) of infants in prevention group were fewer than those in the control group(P<0.01).Adverse reaction was not found.Conclusion Bacillus coagulans Tablets administered after treatment of pneumonia with antibacterial drugs can prevent antibiotic-associated diarrhea.