乳果糖联合美常安治疗成人功能性便秘的临床疗效观察

目的 观察乳果糖联合美常安(枯草杆菌肠球菌二联活菌)治疗成人功能性便秘的疗效及安全性.方法 采用随机分组、平行对照试验.按入选标准选择成人便秘患者64例,随机进入试验组和对照组,每组均为32例.试验组服用乳果糖15 mL bid和美常安500 mg tid；对照组服用乳果糖15 mL bid,疗程2周.观察排便次数、大便性状及便秘伴随症状的变化.结果 试验组48 h首次排便率(78.12％)明显高于对照组(53.33％)(P＜0.05)；试验组平均每周排便次数明显高于对照组(P＜0.01)；治疗后试验组和对照组大便恢复正常率分别为87.50％和60.00％(P＜0.05),试验组腹胀缓解率(84.00％)及排便困难缓解率(92.59％)均明显高于对照组(56.52％和65.38％)(均为P ＜0.05)；试验组总有效率(93.75％)明显高于对照组(73.33％)(P＜0.05)；两组均无严重不良反应发生.结论 乳果糖联合美常安治疗成人功能性便秘比单纯应用乳果糖治疗症状改善快、效果好、安全.

Clinical efficacy of lactulose combined with medilac-s in the treatment of functional constipation

Objective To evaluate the efficacy and safety of lactulose combined with medilac-s in the treatment of functional constipation.Method A total of 64 patients with functional constipation were enrolled in this randomized controlled trial.Patients were divided randomly into two groups,32 patients in each group,to receive lactulose and medilac-s(trial group) or lactulose(control group) for two weeks.Results After treatment,the average of bowel movements in one week in the trial group was more than that of the control group(P<0.01).The stool consistency became normal in 87.50% patients in trial group vs.60% in control group(P<0.05).The constipation and accompanying symptoms such as hard bowel movement and abdominal distension were relieved markedly in the trial group(P<0.05).At the end of the two weeks study,the total effective rates were 93.75% in the trail group and 73.33% in the control group(P<0.05).There were no severe adverse effects in both groups.Conclusion Combination of lactulose and medilac-s is more effective and safer than lactulose alone in the treatment of functional constipation in adults.