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产超广谱β-内酰胺酶大肠埃希菌对喹诺酮类抗菌药物的耐药性检测
引用本文:熊自忠,李涛,李慧,周强.产超广谱β-内酰胺酶大肠埃希菌对喹诺酮类抗菌药物的耐药性检测[J].中国微生态学杂志,2005,17(6):452-453.
作者姓名:熊自忠  李涛  李慧  周强
作者单位:1. 安徽医科大学第一附属医院,感染病科,安徽,合肥,230022
2. 安徽医科大学第一附属医院,检验科,安徽,合肥,230022
基金项目:安徽省高等学校自然科学研究基金资助项目(2005KJ254);安徽省自然科学基金资助项目(050430804)
摘    要:目的 了解临床分离产超广谱β-内酰胺酶(ESBLs)大肠埃希菌对喹诺酮类等抗菌药物的耐药性。方法 NCCLS表型确证试验(纸片增强法)检测出临床分离大肠埃希菌中产ESBLs菌株,琼脂稀释法测定产ESBLs菌株对喹诺酮类等抗菌药物的耐药性。结果 临床分离大肠埃希菌中产ESBLs菌株的检出率为40.2%(92/229),产ESBLs菌株以尿标本多见,对6种喹诺酮类抗菌药物的耐药率均在89%以上,哌拉西林的耐药率为100%;对头孢噻肟、头孢他啶和哌拉西林-三唑巴坦的耐药率分别为77.2%、1.1%和21.7%,对亚胺培南极其敏感,耐药率为0%。结论 产ESBLs大肠埃希菌发生率较高,对喹诺酮类抗菌药物耐药显著,临床应加强检测和监测。

关 键 词:大肠埃希菌  超广谱β-内酰胺酶  喹诺酮类  耐药性
文章编号:1005-376X(2005)06-0452-02
收稿时间:2005-03-09
修稿时间:2005年3月9日

Detection of bacterial resistance to Fluoroquinolones in Escherichia coli isolates
XIONG Zi-zhong, LI Tao, LI Hui,et al..Detection of bacterial resistance to Fluoroquinolones in Escherichia coli isolates[J].Chinese Journal of Microecology,2005,17(6):452-453.
Authors:XIONG Zi-zhong  LI Tao  LI Hui  
Institution:Department of Infectious Diseases, the First Affiliated Hospital, Anhui Medical University, Hefei 230022, China
Abstract:Objective To investigate the bacterial resistance of ESBLs producers in Escherichia coli isolated from our hospital.Methods ESBLs producers in Escherichia coli isolates were detected by NCCLS Phenotypic Confirmatory Test,and susceptibility of those isolates to fluoroquinolones and other antimicrobial agents were tested by agar dilution.Results 40.2% of Escherichia coli isolates were ESBLs producers and most were isolated from urine specimen.The resistant rates of 6 Fluoroquinolones,Piperacillin,Cefotaxime,Ceftazidime,Piperacillin-tazobactam,Imipenem were >89.0%,100%,77.2%,1.1%,21.7%,0%,respectively.Conclusion ESBLs producers were common in Escherichia coli isolates and highly resistant to Fluoroquinolones,and more attention should be paid to survey and detect those strains.
Keywords:
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